Abstract
Cardiac contraction is initiated by Ca2+ leaving the sarcoplasmic reticulum through the ryanodine receptor (RyR). Although opening of the RyR can be modified by various ligands, these have no maintained effect on contraction. We conclude that modulation of the RyR controls sarcoplasmic reticulum Ca2+ content rather than cytoplasmic Ca2+ concentration.
| Original language | English |
|---|---|
| Pages (from-to) | 275-279 |
| Number of pages | 4 |
| Journal | News in Physiological Sciences |
| Volume | 15 |
| Issue number | 5 |
| Publication status | Published - Oct 2000 |