Noise-induced metastability in biochemical networks

Tommaso Biancalani, Tim Rogers, Alan J. McKane

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    Intracellular biochemical reactions exhibit a rich dynamical phenomenology which cannot be explained within the framework of mean-field rate equations and additive noise. Here, we show that the presence of metastable states and radically different time scales are general features of a broad class of autocatalytic reaction networks, and that this fact may be exploited to gain analytical results. The latter point is demonstrated by a treatment of the paradigmatic Togashi-Kaneko reaction, which has resisted theoretical analysis for the last decade. © 2012 American Physical Society.
    Original languageEnglish
    Article number010106
    JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
    Issue number1
    Publication statusPublished - 30 Jul 2012


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