Non-coding RNAs and disease: the classical ncRNAs make a comeback

Rogerio Almeida; Marcin Fraczek; Steven Parker; Daniela Delneri; Raymond O'Keefe

doi:10.1042/BST20160089

Non-coding RNAs and disease: the classical ncRNAs make a comeback

Rogerio Almeida, Marcin Fraczek, Steven Parker, Daniela Delneri, Raymond O'Keefe

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Abstract

Many human diseases have been attributed to mutation in the protein coding regions of the human genome. The protein coding portion of the human genome, however, is very small compared with the non-coding portion of the genome. As such, there are a disproportionate number of diseases attributed to the coding compared with the non-coding portion of the genome. It is now clear that the non-coding portion of the genome produces many functional non-coding RNAs and these RNAs are slowly being linked to human diseases. Here we discuss examples where mutation in classical non-coding RNAs have been attributed to human disease and identify the future potential for the non-coding portion of the genome in disease biology.

Original language	English
Pages (from-to)	1073-1078
Journal	Biochemical Society Transactions
Volume	44
Issue number	4
DOIs	https://doi.org/10.1042/BST20160089
Publication status	Published - 15 Aug 2016

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abstract = "Many human diseases have been attributed to mutation in the protein coding regions of the human genome. The protein coding portion of the human genome, however, is very small compared with the non-coding portion of the genome. As such, there are a disproportionate number of diseases attributed to the coding compared with the non-coding portion of the genome. It is now clear that the non-coding portion of the genome produces many functional non-coding RNAs and these RNAs are slowly being linked to human diseases. Here we discuss examples where mutation in classical non-coding RNAs have been attributed to human disease and identify the future potential for the non-coding portion of the genome in disease biology.",

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AU - Delneri, Daniela

AU - O'Keefe, Raymond

PY - 2016/8/15

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AB - Many human diseases have been attributed to mutation in the protein coding regions of the human genome. The protein coding portion of the human genome, however, is very small compared with the non-coding portion of the genome. As such, there are a disproportionate number of diseases attributed to the coding compared with the non-coding portion of the genome. It is now clear that the non-coding portion of the genome produces many functional non-coding RNAs and these RNAs are slowly being linked to human diseases. Here we discuss examples where mutation in classical non-coding RNAs have been attributed to human disease and identify the future potential for the non-coding portion of the genome in disease biology.

UR - http://www.ncbi.nlm.nih.gov/pubmed/27528754

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JF - Biochemical Society Transactions

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Non-coding RNAs and disease: the classical ncRNAs make a comeback

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