TY - JOUR
T1 - Non-invasive imaging of localised scleroderma for assessment of skin blood flow and structure.
AU - Murray, Andrea
AU - Moore, Tonia
AU - Manning, Joanne
AU - Dinsdale, Graham
AU - Wilkinson, Jack
AU - Bhushan, Monica
AU - Griffiths, Christopher
AU - Herrick, Ariane
PY - 2016
Y1 - 2016
N2 - Extensive morphoea causes major morbidity, disability and disfigurement; pathophysiology is poorly understood. The aim of this study was to investigate, with non-invasive imaging, the relationship between localised abnormalities of skin structure and perfusion, which characterise morphoea. Thirty-two patients with morphoea underwent imaging at affected and unaffected sites. Skin thickness was imaged with optical coherence tomography (OCT) and high-frequency ultrasound (HFUS). Perfusion was imaged with dual-wavelength laser Doppler imaging (LDI) and thermography. Epidermal thickness showed a small increase from affected to unaffected site (OCT, active and inactive plaques [p = 0.005 and p = 0.004], HFUS active plaques only [p = 0.03]). Deeper perfusion was higher within affected than unaffected sites (LDI p
AB - Extensive morphoea causes major morbidity, disability and disfigurement; pathophysiology is poorly understood. The aim of this study was to investigate, with non-invasive imaging, the relationship between localised abnormalities of skin structure and perfusion, which characterise morphoea. Thirty-two patients with morphoea underwent imaging at affected and unaffected sites. Skin thickness was imaged with optical coherence tomography (OCT) and high-frequency ultrasound (HFUS). Perfusion was imaged with dual-wavelength laser Doppler imaging (LDI) and thermography. Epidermal thickness showed a small increase from affected to unaffected site (OCT, active and inactive plaques [p = 0.005 and p = 0.004], HFUS active plaques only [p = 0.03]). Deeper perfusion was higher within affected than unaffected sites (LDI p
U2 - 10.2340/00015555-2328
DO - 10.2340/00015555-2328
M3 - Article
C2 - 26695444
SN - 1651-2057
VL - 96
SP - 641
EP - 644
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
IS - 5
ER -