Noncoding RNA of glutamine synthetase I modulates antibiotic production in Streptomyces coelicolor A3(2)

Davide D'Alia; Kay Nieselt; Stephan Steigele; Jonas Müller; Ilse Verburg; Eriko Takano

doi:10.1128/JB.01374-09

Noncoding RNA of glutamine synthetase I modulates antibiotic production in Streptomyces coelicolor A3(2)

Davide D'Alia, Kay Nieselt, Stephan Steigele, Jonas Müller, Ilse Verburg, Eriko Takano

Research output: Contribution to journal › Article › peer-review

Abstract

Overexpression of antisense chromosomal cis-encoded noncoding RNAss (ncRNAs) in glutamine synthetase I resulted in a decrease in growth, protein synthesis, and antibiotic production in Streptomyces coelicolor. In addition, we predicted 3,597 cis-encoded ncRNAs and validated 13 of them experimentally, including several ncRNAs that are differentially expressed in bacterial hormone-defective mutants. Copyright © 2010, American Society for Microbiology. All Rights Reserved.

Original language	English
Pages (from-to)	1160-1164
Number of pages	4
Journal	Journal of Bacteriology
Volume	192
Issue number	4
DOIs	https://doi.org/10.1128/JB.01374-09
Publication status	Published - Feb 2010

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http://jb.asm.org/cgi/reprint/192/4/1160

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title = "Noncoding RNA of glutamine synthetase I modulates antibiotic production in Streptomyces coelicolor A3(2)",

abstract = "Overexpression of antisense chromosomal cis-encoded noncoding RNAss (ncRNAs) in glutamine synthetase I resulted in a decrease in growth, protein synthesis, and antibiotic production in Streptomyces coelicolor. In addition, we predicted 3,597 cis-encoded ncRNAs and validated 13 of them experimentally, including several ncRNAs that are differentially expressed in bacterial hormone-defective mutants. Copyright {\textcopyright} 2010, American Society for Microbiology. All Rights Reserved.",

author = "Davide D'Alia and Kay Nieselt and Stephan Steigele and Jonas M{\"u}ller and Ilse Verburg and Eriko Takano",

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AU - Steigele, Stephan

AU - Müller, Jonas

AU - Verburg, Ilse

AU - Takano, Eriko

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AB - Overexpression of antisense chromosomal cis-encoded noncoding RNAss (ncRNAs) in glutamine synthetase I resulted in a decrease in growth, protein synthesis, and antibiotic production in Streptomyces coelicolor. In addition, we predicted 3,597 cis-encoded ncRNAs and validated 13 of them experimentally, including several ncRNAs that are differentially expressed in bacterial hormone-defective mutants. Copyright © 2010, American Society for Microbiology. All Rights Reserved.

U2 - 10.1128/JB.01374-09

DO - 10.1128/JB.01374-09

M3 - Article

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EP - 1164

JO - Journal of Bacteriology

JF - Journal of Bacteriology

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Noncoding RNA of glutamine synthetase I modulates antibiotic production in Streptomyces coelicolor A3(2)

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