Noninvasive in vivo demonstration of the connections of the human parahippocampal gyrus

H. W R Powell; M. Guye; G. J M Parker; M. R. Symms; P. Boulby; M. J. Koepp; Gareth J. Barker; J. S. Duncan

doi:10.1016/j.neuroimage.2004.01.011

Noninvasive in vivo demonstration of the connections of the human parahippocampal gyrus

H. W R Powell, M. Guye, G. J M Parker, M. R. Symms, P. Boulby, M. J. Koepp, Gareth J. Barker, J. S. Duncan

Research output: Contribution to journal › Article › peer-review

Abstract

MR tractography techniques provide a method for noninvasively studying white matter pathways in vivo. In this study we have used diffusion tensor imaging (DTI) and the fast marching tractography (FMT) algorithm to plot the structural connectivity of the human parahippocampal gyrus (PHG) in 10 healthy subjects, using seed points selected in the anterior parahippocampal gyrus. Our results demonstrate connectivity between the parahippocampal gyrus and the anterior temporal lobe, orbitofrontal areas, posterior temporal lobe and extrastriate occipital lobe via the lingual and fusiform gyri. We also demonstrate for the first time noninvasively direct connectivity between the parahippocampal gyrus and the hippocampus itself. These results agree with previous histological tract-tracing studies in animals. The connections demonstrated between neocortical areas and the hippocampus via the parahippocampal gyrus may provide the structural basis for theoretical models of memory and higher visual processing. © 2004 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	740-747
Number of pages	7
Journal	NeuroImage
Volume	22
Issue number	2
DOIs	https://doi.org/10.1016/j.neuroimage.2004.01.011
Publication status	Published - Jun 2004

Keywords

Hippocampus
Noninvasive
Parahippocampal gyrus

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10.1016/j.neuroimage.2004.01.011

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title = "Noninvasive in vivo demonstration of the connections of the human parahippocampal gyrus",

abstract = "MR tractography techniques provide a method for noninvasively studying white matter pathways in vivo. In this study we have used diffusion tensor imaging (DTI) and the fast marching tractography (FMT) algorithm to plot the structural connectivity of the human parahippocampal gyrus (PHG) in 10 healthy subjects, using seed points selected in the anterior parahippocampal gyrus. Our results demonstrate connectivity between the parahippocampal gyrus and the anterior temporal lobe, orbitofrontal areas, posterior temporal lobe and extrastriate occipital lobe via the lingual and fusiform gyri. We also demonstrate for the first time noninvasively direct connectivity between the parahippocampal gyrus and the hippocampus itself. These results agree with previous histological tract-tracing studies in animals. The connections demonstrated between neocortical areas and the hippocampus via the parahippocampal gyrus may provide the structural basis for theoretical models of memory and higher visual processing. {\textcopyright} 2004 Elsevier Inc. All rights reserved.",

keywords = "Hippocampus, Noninvasive, Parahippocampal gyrus",

author = "Powell, {H. W R} and M. Guye and Parker, {G. J M} and Symms, {M. R.} and P. Boulby and Koepp, {M. J.} and Barker, {Gareth J.} and Duncan, {J. S.}",

year = "2004",

month = jun,

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journal = "NeuroImage",

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TY - JOUR

T1 - Noninvasive in vivo demonstration of the connections of the human parahippocampal gyrus

AU - Powell, H. W R

AU - Guye, M.

AU - Parker, G. J M

AU - Symms, M. R.

AU - Boulby, P.

AU - Koepp, M. J.

AU - Barker, Gareth J.

AU - Duncan, J. S.

PY - 2004/6

Y1 - 2004/6

N2 - MR tractography techniques provide a method for noninvasively studying white matter pathways in vivo. In this study we have used diffusion tensor imaging (DTI) and the fast marching tractography (FMT) algorithm to plot the structural connectivity of the human parahippocampal gyrus (PHG) in 10 healthy subjects, using seed points selected in the anterior parahippocampal gyrus. Our results demonstrate connectivity between the parahippocampal gyrus and the anterior temporal lobe, orbitofrontal areas, posterior temporal lobe and extrastriate occipital lobe via the lingual and fusiform gyri. We also demonstrate for the first time noninvasively direct connectivity between the parahippocampal gyrus and the hippocampus itself. These results agree with previous histological tract-tracing studies in animals. The connections demonstrated between neocortical areas and the hippocampus via the parahippocampal gyrus may provide the structural basis for theoretical models of memory and higher visual processing. © 2004 Elsevier Inc. All rights reserved.

AB - MR tractography techniques provide a method for noninvasively studying white matter pathways in vivo. In this study we have used diffusion tensor imaging (DTI) and the fast marching tractography (FMT) algorithm to plot the structural connectivity of the human parahippocampal gyrus (PHG) in 10 healthy subjects, using seed points selected in the anterior parahippocampal gyrus. Our results demonstrate connectivity between the parahippocampal gyrus and the anterior temporal lobe, orbitofrontal areas, posterior temporal lobe and extrastriate occipital lobe via the lingual and fusiform gyri. We also demonstrate for the first time noninvasively direct connectivity between the parahippocampal gyrus and the hippocampus itself. These results agree with previous histological tract-tracing studies in animals. The connections demonstrated between neocortical areas and the hippocampus via the parahippocampal gyrus may provide the structural basis for theoretical models of memory and higher visual processing. © 2004 Elsevier Inc. All rights reserved.

KW - Hippocampus

KW - Noninvasive

KW - Parahippocampal gyrus

U2 - 10.1016/j.neuroimage.2004.01.011

DO - 10.1016/j.neuroimage.2004.01.011

M3 - Article

SN - 1053-8119

VL - 22

SP - 740

EP - 747

JO - NeuroImage

JF - NeuroImage

IS - 2

ER -

Noninvasive in vivo demonstration of the connections of the human parahippocampal gyrus

Abstract

Keywords

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