| Original language | English |
|---|---|
| Article number | e13777 |
| Journal | Pediatric allergy and immunology |
| Volume | 33 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2022 |
Keywords
- ALSPAC
- childhood asthma
- meta-analysis
- parental smoking
- polygenic risk score
- PRS-by-environment interactions
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Nonlinear effects of environment on childhood asthma susceptibility. / STELAR/UNICORN investigators.
In: Pediatric allergy and immunology, Vol. 33, No. 4, e13777, 04.2022.Research output: Contribution to journal › Letter › peer-review
TY - JOUR
T1 - Nonlinear effects of environment on childhood asthma susceptibility
AU - STELAR/UNICORN investigators
AU - Kothalawala, Dilini M.
AU - Weiss, Veronique B.N.
AU - Kadalayil, Latha
AU - Granell, Raquel
AU - Curtin, John A.
AU - Murray, Clare S.
AU - Simpson, Angela
AU - Custovic, Adnan
AU - Tapper, William J.
AU - Rezwan, Faisal I.
AU - Arshad, Syed Hasan
AU - Holloway, John W.
AU - Roberts, Graham C.
AU - Turner, Steve W.
AU - Haider, Sadia
AU - Fontanella, Sara
AU - Cullinan, Paul
N1 - Funding Information: This work was supported by the NIHR Southampton Biomedical Research Centre and a University of Southampton Presidential Research Studentship. The 10‐year follow‐up of the IOWBC was supported by the National Asthma Campaign, UK (Grant No 364). MAAS was supported by the Asthma UK Grants No 301 (1995‐1998), No 362 (1998‐2001), No 01/012 (2001‐2004), No 04/014 (2004‐2007), BMA James Trust (2005), and the JP Moulton Charitable Foundation (2004‐current), the North West Lung Centre Charity (1997‐current), and the Medical Research Council (MRC) G0601361 (2007‐2012), MR/K002449/1 (2013‐2014), and MR/L012693/1 (2014‐2018). UNICORN (Unified Cohorts Research Network): Disaggregating asthma MR/S025340/1. The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. GWAS data were generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. RG is in part funded through Wellcome Trust Strategic Award 108818/15/Z. Funding Information: This work was supported by the NIHR Southampton Biomedical Research Centre and a University of Southampton Presidential Research Studentship. The 10-year follow-up of the IOWBC was supported by the National Asthma Campaign, UK (Grant No 364). MAAS was supported by the Asthma UK Grants No 301 (1995-1998), No 362 (1998-2001), No 01/012 (2001-2004), No 04/014 (2004-2007), BMA James Trust (2005), and the JP Moulton Charitable Foundation (2004-current), the North West Lung Centre Charity (1997-current), and the Medical Research Council (MRC) G0601361 (2007-2012), MR/K002449/1 (2013-2014), and MR/L012693/1 (2014-2018). UNICORN (Unified Cohorts Research Network): Disaggregating asthma MR/S025340/1. The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. GWAS data were generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. RG is in part funded through Wellcome Trust Strategic Award 108818/15/Z.
PY - 2022/4
Y1 - 2022/4
KW - ALSPAC
KW - childhood asthma
KW - meta-analysis
KW - parental smoking
KW - polygenic risk score
KW - PRS-by-environment interactions
UR - http://www.scopus.com/inward/record.url?scp=85129778741&partnerID=8YFLogxK
U2 - 10.1111/pai.13777
DO - 10.1111/pai.13777
M3 - Letter
C2 - 35470933
AN - SCOPUS:85129778741
VL - 33
JO - Pediatric Allergy and Immunology
JF - Pediatric Allergy and Immunology
SN - 0905-6157
IS - 4
M1 - e13777
ER -