TY - JOUR
T1 - Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activity
AU - Hilker, Ruediger
AU - Schweitzer, Katherine
AU - Coburger, Silke
AU - Ghaemi, Mehran
AU - Weisenbach, Simon
AU - Jacobs, Andreas H.
AU - Rudolf, Jobst
AU - Herholz, Karl
AU - Heiss, Wolf Dieter
PY - 2005/3
Y1 - 2005/3
N2 - Background: The investigation of disease progression provides important information on the dynamics of cell death in Parkinson disease (PD). Objective: To determine the progression of dopaminergic impairment in PD with the use of positron emission tomography (PET). Design: Longitudinal prospective cohort study with a follow-up period of 64.5±22.6 months (mean±SD). Setting: University hospital. Patients: A consecutive sample of patients with PD (N = 31; age at symptom onset, 53.6±11.3 years) with a wide range of symptom duration and severity at the time of study entry. Interventions: Investigation by serial fluorodopa F 18 ([18F]fluorodopa) PET as a marker for striatal dopaminergic function. Main Outcome Measures: Changes in caudate and putaminal [18F]fluorodopa influx constant (Ki) values. Results: In patients with PD, the decline rate of putaminal [ 18F]fluorodopa Ki correlated inversely with disease duration before study inclusion (r=-0.46, P=.01) and positively with baseline Ki values (r=0.44, P=.01), indicating a negative exponential loss of dopamine neurons. Annual disease progression rates ranged from 4.4% in the caudate nucleus to 6.3% in the putamen. A mean preclinical period of 5.6±3.2 years was calculated with symptom onset at a putaminal K i threshold of 69% from controls. Assuming nonlinear progression kinetics, the required sample size to prove neuroprotection with the use of [18F]fluorodopa PET was found to increase strongly with the preceding symptom duration of study subjects. Conclusion: These data suggest that the neurodegenerative process in PD follows a negative exponential course and slows down with increasing symptom duration, contradicting the long-latency hypothesis of PD.
AB - Background: The investigation of disease progression provides important information on the dynamics of cell death in Parkinson disease (PD). Objective: To determine the progression of dopaminergic impairment in PD with the use of positron emission tomography (PET). Design: Longitudinal prospective cohort study with a follow-up period of 64.5±22.6 months (mean±SD). Setting: University hospital. Patients: A consecutive sample of patients with PD (N = 31; age at symptom onset, 53.6±11.3 years) with a wide range of symptom duration and severity at the time of study entry. Interventions: Investigation by serial fluorodopa F 18 ([18F]fluorodopa) PET as a marker for striatal dopaminergic function. Main Outcome Measures: Changes in caudate and putaminal [18F]fluorodopa influx constant (Ki) values. Results: In patients with PD, the decline rate of putaminal [ 18F]fluorodopa Ki correlated inversely with disease duration before study inclusion (r=-0.46, P=.01) and positively with baseline Ki values (r=0.44, P=.01), indicating a negative exponential loss of dopamine neurons. Annual disease progression rates ranged from 4.4% in the caudate nucleus to 6.3% in the putamen. A mean preclinical period of 5.6±3.2 years was calculated with symptom onset at a putaminal K i threshold of 69% from controls. Assuming nonlinear progression kinetics, the required sample size to prove neuroprotection with the use of [18F]fluorodopa PET was found to increase strongly with the preceding symptom duration of study subjects. Conclusion: These data suggest that the neurodegenerative process in PD follows a negative exponential course and slows down with increasing symptom duration, contradicting the long-latency hypothesis of PD.
U2 - 10.1001/archneur.62.3.378
DO - 10.1001/archneur.62.3.378
M3 - Article
SN - 1538-3687
VL - 62
SP - 378
EP - 382
JO - Archives of Neurology
JF - Archives of Neurology
IS - 3
ER -