Normal tissue reactions to radiotherapy: Towards tailoring treatment dose by genotype

Gillian C. Barnett; Catherine M L West; Alison M. Dunning; Rebecca M. Elliott; Charlotte E. Coles; Paul D P Pharoah; Neil G. Burnet

doi:10.1038/nrc2587

Normal tissue reactions to radiotherapy: Towards tailoring treatment dose by genotype

Gillian C. Barnett, Catherine M L West, Alison M. Dunning, Rebecca M. Elliott, Charlotte E. Coles, Paul D P Pharoah, Neil G. Burnet

Research output: Contribution to journal › Article › peer-review

Abstract

A key challenge in radiotherapy is to maximize radiation doses to cancer cells while minimizing damage to surrounding healthy tissue. As severe toxicity in a minority of patients limits the doses that can be safely given to the majority, there is interest in developing a test to measure an individual's radiosensitivity before treatment. Variation in sensitivity to radiation is an inherited genetic trait and recent progress in genotyping raises the possibility of genome-wide studies to characterize genetic profiles that predict patient response to radiotherapy. © 2009 Macmillan Publishers Limited. All rights reserved.

Original language	English
Pages (from-to)	134-142
Number of pages	8
Journal	Nature Reviews Cancer
Volume	9
Issue number	2
DOIs	https://doi.org/10.1038/nrc2587
Publication status	Published - Feb 2009

Keywords

radiation effects: Cell Survival
Dose-Response Relationship, Radiation
Genotype
Humans
genetics: Neoplasms
Radiation Tolerance
adverse effects: Radiotherapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nrc2587

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title = "Normal tissue reactions to radiotherapy: Towards tailoring treatment dose by genotype",

abstract = "A key challenge in radiotherapy is to maximize radiation doses to cancer cells while minimizing damage to surrounding healthy tissue. As severe toxicity in a minority of patients limits the doses that can be safely given to the majority, there is interest in developing a test to measure an individual's radiosensitivity before treatment. Variation in sensitivity to radiation is an inherited genetic trait and recent progress in genotyping raises the possibility of genome-wide studies to characterize genetic profiles that predict patient response to radiotherapy. {\textcopyright} 2009 Macmillan Publishers Limited. All rights reserved.",

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author = "Barnett, {Gillian C.} and West, {Catherine M L} and Dunning, {Alison M.} and Elliott, {Rebecca M.} and Coles, {Charlotte E.} and Pharoah, {Paul D P} and Burnet, {Neil G.}",

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doi = "10.1038/nrc2587",

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T1 - Normal tissue reactions to radiotherapy: Towards tailoring treatment dose by genotype

AU - Barnett, Gillian C.

AU - West, Catherine M L

AU - Dunning, Alison M.

AU - Elliott, Rebecca M.

AU - Coles, Charlotte E.

AU - Pharoah, Paul D P

AU - Burnet, Neil G.

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N2 - A key challenge in radiotherapy is to maximize radiation doses to cancer cells while minimizing damage to surrounding healthy tissue. As severe toxicity in a minority of patients limits the doses that can be safely given to the majority, there is interest in developing a test to measure an individual's radiosensitivity before treatment. Variation in sensitivity to radiation is an inherited genetic trait and recent progress in genotyping raises the possibility of genome-wide studies to characterize genetic profiles that predict patient response to radiotherapy. © 2009 Macmillan Publishers Limited. All rights reserved.

AB - A key challenge in radiotherapy is to maximize radiation doses to cancer cells while minimizing damage to surrounding healthy tissue. As severe toxicity in a minority of patients limits the doses that can be safely given to the majority, there is interest in developing a test to measure an individual's radiosensitivity before treatment. Variation in sensitivity to radiation is an inherited genetic trait and recent progress in genotyping raises the possibility of genome-wide studies to characterize genetic profiles that predict patient response to radiotherapy. © 2009 Macmillan Publishers Limited. All rights reserved.

KW - radiation effects: Cell Survival

KW - Dose-Response Relationship, Radiation

KW - Genotype

KW - Humans

KW - genetics: Neoplasms

KW - Radiation Tolerance

KW - adverse effects: Radiotherapy

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JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 2

ER -

Normal tissue reactions to radiotherapy: Towards tailoring treatment dose by genotype

Abstract

Keywords

UN SDGs

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