Novel 3D Bioglass scaffolds for bone tissue regeneration

Evangelos Daskalakis, Boyang Huang, Cian Vyas, Anil Ahmet Acar , Ali Fallah, Glen Cooper, Andrew Weightman, Gordon Blunn, Bahhatin Koc, Paulo Jorge Da Silva Bartolo

Research output: Contribution to journalArticlepeer-review

Abstract

The design of scaffolds with optimal biomechanical properties for load bearing applications is an important topic of research. Most studies addressed this problem focusing on the material composition and not on the coupled effect between material composition and scaffold architecture. Polymer/bioglass scaffolds have been investigated due to the excellent bioactivity properties of bioglass that releases ions that activate osteogenesis. However, material preparation methods usually required the use of organic solvents that induces surface modifications on the bioglass particles compromising the adhesion with the polymeric material thus compromising mechanical properties. In this paper we used a simple melt blending approach to produce polycaprolactone/bioglass pellets to produce scaffolds with pore size gradient. Results show that the addition of bioglass particles improve the mechanical properties of the scaffolds and, due to the selected architecture, all scaffolds present mechanical properties in the cortical bone region. Moreover, the addition of bioglass indicate a positive long-term effect on the biological performance of the scaffolds. The pore size gradient also induced a cell spreading gradient.
Original languageEnglish
JournalPolymers
Volume14
Issue number3
Early online date22 Jan 2022
DOIs
Publication statusPublished - 1 Feb 2022

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