Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation

Eun A. Raiber; James A. Wilkinson; Fabrizio Manetti; Maurizio Botta; Jon Deakin; John Gallagher; Malcolm Lyon; Sylvie W. Ducki

Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation

Eun A. Raiber, James A. Wilkinson, Fabrizio Manetti, Maurizio Botta, Jon Deakin, John Gallagher, Malcolm Lyon, Sylvie W. Ducki

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of simple, non-sugar glycosaminoglycan (GAG) mimics has been achieved and the analogues evaluated for their ability to inhibit the activation of the MET receptor by hepatocyte growth factor/scatter factor (HGF/SF). © 2007 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	6321-6325
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	22
Publication status	Published - 15 Nov 2007

Keywords

Glycosaminoglycan (GAG)
Heparin/heparan sulfate (H/HS)
Hepatocyte growth factor/scatter factor (HGF/SF)
Non-carbohydrate mimic
Tyrosine kinase receptor MET

Cite this

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title = "Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation",

abstract = "The synthesis of simple, non-sugar glycosaminoglycan (GAG) mimics has been achieved and the analogues evaluated for their ability to inhibit the activation of the MET receptor by hepatocyte growth factor/scatter factor (HGF/SF). {\textcopyright} 2007 Elsevier Ltd. All rights reserved.",

keywords = "Glycosaminoglycan (GAG), Heparin/heparan sulfate (H/HS), Hepatocyte growth factor/scatter factor (HGF/SF), Non-carbohydrate mimic, Tyrosine kinase receptor MET",

author = "Raiber, {Eun A.} and Wilkinson, {James A.} and Fabrizio Manetti and Maurizio Botta and Jon Deakin and John Gallagher and Malcolm Lyon and Ducki, {Sylvie W.}",

year = "2007",

month = nov,

day = "15",

language = "English",

volume = "17",

pages = "6321--6325",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "1464-3405",

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TY - JOUR

T1 - Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation

AU - Raiber, Eun A.

AU - Wilkinson, James A.

AU - Manetti, Fabrizio

AU - Botta, Maurizio

AU - Deakin, Jon

AU - Gallagher, John

AU - Lyon, Malcolm

AU - Ducki, Sylvie W.

PY - 2007/11/15

Y1 - 2007/11/15

N2 - The synthesis of simple, non-sugar glycosaminoglycan (GAG) mimics has been achieved and the analogues evaluated for their ability to inhibit the activation of the MET receptor by hepatocyte growth factor/scatter factor (HGF/SF). © 2007 Elsevier Ltd. All rights reserved.

AB - The synthesis of simple, non-sugar glycosaminoglycan (GAG) mimics has been achieved and the analogues evaluated for their ability to inhibit the activation of the MET receptor by hepatocyte growth factor/scatter factor (HGF/SF). © 2007 Elsevier Ltd. All rights reserved.

KW - Glycosaminoglycan (GAG)

KW - Heparin/heparan sulfate (H/HS)

KW - Hepatocyte growth factor/scatter factor (HGF/SF)

KW - Non-carbohydrate mimic

KW - Tyrosine kinase receptor MET

M3 - Article

SN - 1464-3405

VL - 17

SP - 6321

EP - 6325

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 22

ER -

Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation

Abstract

Keywords

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