Novel isomenthone-derived 1,3-diol ligands identified through parallel synthesis and screening catalyse an asymmetric aldol reaction

John M. Gardiner; Philip D. Crewe; Gillian E. Smith; Kenneth T. Veal

doi:10.1039/b212769p

Novel isomenthone-derived 1,3-diol ligands identified through parallel synthesis and screening catalyse an asymmetric aldol reaction

John M. Gardiner, Philip D. Crewe, Gillian E. Smith, Kenneth T. Veal

Research output: Contribution to journal › Article › peer-review

Abstract

A library of new (+)-isomenthone-derived 1,3-diol ligands, containing 5 contiguous stereocentres (3 fixed, 2 variable), was prepared in 2 steps by parallel synthesis. Evaluation in parallel identified several different ligands from the library for catalysing a Mukaiyama aldol reaction with 87-90% e.e.

Original language	English
Pages (from-to)	618-619
Number of pages	1
Journal	Chemical Communications
Volume	9
Issue number	5
DOIs	https://doi.org/10.1039/b212769p
Publication status	Published - 7 Mar 2003

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title = "Novel isomenthone-derived 1,3-diol ligands identified through parallel synthesis and screening catalyse an asymmetric aldol reaction",

abstract = "A library of new (+)-isomenthone-derived 1,3-diol ligands, containing 5 contiguous stereocentres (3 fixed, 2 variable), was prepared in 2 steps by parallel synthesis. Evaluation in parallel identified several different ligands from the library for catalysing a Mukaiyama aldol reaction with 87-90% e.e.",

author = "Gardiner, {John M.} and Crewe, {Philip D.} and Smith, {Gillian E.} and Veal, {Kenneth T.}",

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AU - Crewe, Philip D.

AU - Smith, Gillian E.

AU - Veal, Kenneth T.

PY - 2003/3/7

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DO - 10.1039/b212769p

M3 - Article

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EP - 619

JO - Chemical Communications

JF - Chemical Communications

IS - 5

ER -

Novel isomenthone-derived 1,3-diol ligands identified through parallel synthesis and screening catalyse an asymmetric aldol reaction

Abstract

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