Novel mechanism for temperature-independent transitions in flexible molecules: Role of thermodynamic fluctuations

V. I. Teslenko, E. G. Petrov, A. Verkhratsky, O. A. Krishtal

    Research output: Contribution to journalArticlepeer-review

    Abstract

    A novel physical mechanism is proposed to explain the temperature- independent transition reactions in molecular systems. The mechanism becomes effective in the case of conformation transitions between quasi-isoenergetic molecular states. It is shown that at room temperatures, stochastic broadening of molecular energy levels predominates the energy of low-frequency vibrations accompanying the transition. This leads to a cancellation of temperature dependence in the stochastically averaged rate constants. As an example, a physical interpretation of temperature-independent onset of P2X3 receptor desensitization in neuronal membranes is provided. © 2010 The American Physical Society.
    Original languageEnglish
    Article number178105
    JournalPhysical Review Letters
    Volume104
    Issue number17
    DOIs
    Publication statusPublished - 29 Apr 2010

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