Novel microsystems for concentration gradient generation through computer optimization with validation using optical instrumentation

Novel microfluidic resistive network designs have been evaluated theoretically and experimentally. Such networks are an important component of microreactor technology and are used in analytical and biomedical applications for precisely controlled and evenly stepped dilution. A detailed model and a simplification algorithm have been devised for these networks. Their combination produces novel simplified network designs that exhibit less hierarchical branching over existing network designs. Rapid prediction and optimization of a layout that meets an arbitrary outlet profile is also possible. High levels of linearity were achieved on three microdevice fluidic networks. Good agreement of the experimental results from tested devices with the model was obtained. In addition, CFD simulation of one of the designs gave good agreement with results from the model presented, a good linear outlet profile being obtained. © 2008 Elsevier B.V. All rights reserved.