Novel poly(ε-caprolactone)/graphene scaffolds for bone cancer treatment and bone regeneration

Yanhao Hou, Weiguang Wang, Paulo Jorge Da Silva Bartolo

Research output: Contribution to journalArticlepeer-review


Scaffold-based bone tissue engineering is the most relevant approaches for critical-size bone defects. It is based on the use of three-dimensional substrates to provide the appropriate biomechanical environment for bone regeneration. Despite some successful results previously reported, scaffolds were never designed for diseases treatment applications. This paper proposes a novel dual-functional scaffold for cancer applications, comprising both treatment and regeneration functions. These functions are achieved by combining a biocompatible and biodegradable polymer and graphene. Results indicate that high concentrations of graphene enhance the mechanical properties of the scaffolds, increasing also the inhibition on cancer cell viability and proliferation.
Original languageEnglish
Pages (from-to)222-229
Number of pages8
Journal3D Printing and Additive Manufacturing
Issue number5
Publication statusPublished - 15 Oct 2020


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