Abstract
INTRODUCTION: The immunopathogenesis of psoriasis has led to the discovery and development of several promising treatment options for psoriasis, including those that target the IL-17 and IL-23 pathways as well as small molecules that act on intracellular signaling pathways including the Janus kinase inhibitor and phosphodiesterase-4 inhibitor. Studies have demonstrated efficacy although long-term risks are not fully known. This review looks at novel systemic therapies for psoriasis that have emerged recently. Areas covered: Systemic treatments for psoriasis that are in the late phase of development were reviewed, with the main focus on the efficacy and adverse effects of individual treatments. Expert opinion: The future of psoriasis treatment is likely to be based on clinical, genetic and immune biomarkers that will individualize treatment and may potentially optimize disease outcome.
Original language | English |
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Journal | Expert opinion on pharmacotherapy |
DOIs | |
Publication status | Published - 7 Nov 2015 |
Keywords
- IL-17
- IL-23
- JAK inhibitor
- biologic
- novel
- phosphodiesterase-4 inhibitor
- psoriasis
- small molecules
- systemic