Novel targets and interaction partners of mutant p53 Gain-Of-Function

Lydia Aschauer, Patricia A.J. Muller

Research output: Contribution to journalReview articlepeer-review

Abstract

In many human cancers p53 expression is lost or a mutant p53 protein is expressed. Over the past 15 years it has become apparent that a large number of these mutant p53 proteins have lost wild type function, but more importantly have gained functions that promote tumorigenesis and drive chemo-resistance, invasion and metastasis. Many researchers have investigated the underlying mechanisms of these Gain-Of-Functions (GOFs) and it has become apparent that many of these functions are the result of mutant p53 hijacking other transcription factors. In this review, we summarize the latest research on p53 GOF and categorize these in light of the hallmarks of cancer as presented by Hannahan and Weinberg.

Original languageEnglish
Pages (from-to)460-466
Number of pages7
JournalBiochemical Society Transactions
Volume44
Issue number2
Early online date11 Apr 2016
DOIs
Publication statusPublished - 15 Apr 2016

Keywords

  • Gain-Of-Function
  • Hallmarks of cancer
  • Mutant p53

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre

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