Nuclear factor (erythroid-derived 2)-like-2 pathway modulates substance P–induced human mast cell activation and degranulation in the hair follicle

Laura Jadkauskaite, Rajia Bahri, Nilofer Farjo, Bessam Farjo, Gail Jenkins, Ranjit Bhogal, Iain Haslam, Silvia Bulfone-Paus, Ralf Paus

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Abstract

Activation of Nrf2 in primary human mast cells exposed to oxidative stress induced by substance P suppresses pro-inflammatory gene transcription, activation and degranulation.
Original languageEnglish
Pages (from-to)1331-1333.e8
JournalJournal of Allergy and Clinical Immunology
Volume142
Issue number4
Early online date30 May 2018
DOIs
Publication statusPublished - Oct 2018

Keywords

  • mast cells
  • Nrf2
  • Oxidative stress
  • hair follicle
  • Substance P

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