Nuclear imaging of neuroinflammation: A comprehensive review of [ 11C]PK11195 challengers

Fabien Chauveau; Hervé Boutin; Nadja Van Camp; Frédéric Dollé; Bertrand Tavitian

doi:10.1007/s00259-008-0908-9

Nuclear imaging of neuroinflammation: A comprehensive review of [ 11C]PK11195 challengers

Fabien Chauveau, Hervé Boutin, Nadja Van Camp, Frédéric Dollé, Bertrand Tavitian

Research output: Contribution to journal › Article › peer-review

Abstract

Neurodegenerative, inflammatory and neoplastic brain disorders involve neuroinflammatory reactions, and a biomarker of neuroinflammation would be useful for diagnostic, drug development and therapy control of these frequent diseases. In vivo imaging can document the expression of the peripheral benzodiazepine receptor (PBR)/translocator protein 18 kDa (TSPO) that is linked to microglial activation and considered a hallmark of neuroinflammation. The prototype positron emission tomography tracer for PBR, [11C]PK11195, has shown limitations that until now have slowed the clinical applications of PBR imaging. In recent years, dozens of new PET and SPECT radioligands for the PBR have been radiolabelled, and several have been evaluated in imaging protocols. Here we review the new PBR ligands proposed as challengers of [ 11C]PK11195, critically analyze preclinical imaging studies and discuss their potential as neuroinflammation imaging agents. © 2008 Springer-Verlag.

Original language	English
Pages (from-to)	2304-2319
Number of pages	15
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Volume	35
Issue number	12
DOIs	https://doi.org/10.1007/s00259-008-0908-9
Publication status	Published - Dec 2008

Keywords

[11C]PK11195
Neuroinflammation
Peripheral benzodiazepine receptor (PBR)
PET
Translocator protein 18kDa (TSPO)

Access to Document

10.1007/s00259-008-0908-9

Cite this

@article{22cc3c3abdcc4909b48b66e590c63093,

title = "Nuclear imaging of neuroinflammation: A comprehensive review of [ 11C]PK11195 challengers",

abstract = "Neurodegenerative, inflammatory and neoplastic brain disorders involve neuroinflammatory reactions, and a biomarker of neuroinflammation would be useful for diagnostic, drug development and therapy control of these frequent diseases. In vivo imaging can document the expression of the peripheral benzodiazepine receptor (PBR)/translocator protein 18 kDa (TSPO) that is linked to microglial activation and considered a hallmark of neuroinflammation. The prototype positron emission tomography tracer for PBR, [11C]PK11195, has shown limitations that until now have slowed the clinical applications of PBR imaging. In recent years, dozens of new PET and SPECT radioligands for the PBR have been radiolabelled, and several have been evaluated in imaging protocols. Here we review the new PBR ligands proposed as challengers of [ 11C]PK11195, critically analyze preclinical imaging studies and discuss their potential as neuroinflammation imaging agents. {\textcopyright} 2008 Springer-Verlag.",

keywords = "[11C]PK11195, Neuroinflammation, Peripheral benzodiazepine receptor (PBR), PET, Translocator protein 18kDa (TSPO)",

author = "Fabien Chauveau and Herv{\'e} Boutin and {Van Camp}, Nadja and Fr{\'e}d{\'e}ric Doll{\'e} and Bertrand Tavitian",

year = "2008",

month = dec,

doi = "10.1007/s00259-008-0908-9",

language = "English",

volume = "35",

pages = "2304--2319",

journal = "European Journal of Nuclear Medicine and Molecular Imaging",

issn = "1619-7070",

publisher = "Springer Nature",

number = "12",

}

TY - JOUR

T1 - Nuclear imaging of neuroinflammation: A comprehensive review of [ 11C]PK11195 challengers

AU - Chauveau, Fabien

AU - Boutin, Hervé

AU - Van Camp, Nadja

AU - Dollé, Frédéric

AU - Tavitian, Bertrand

PY - 2008/12

Y1 - 2008/12

N2 - Neurodegenerative, inflammatory and neoplastic brain disorders involve neuroinflammatory reactions, and a biomarker of neuroinflammation would be useful for diagnostic, drug development and therapy control of these frequent diseases. In vivo imaging can document the expression of the peripheral benzodiazepine receptor (PBR)/translocator protein 18 kDa (TSPO) that is linked to microglial activation and considered a hallmark of neuroinflammation. The prototype positron emission tomography tracer for PBR, [11C]PK11195, has shown limitations that until now have slowed the clinical applications of PBR imaging. In recent years, dozens of new PET and SPECT radioligands for the PBR have been radiolabelled, and several have been evaluated in imaging protocols. Here we review the new PBR ligands proposed as challengers of [ 11C]PK11195, critically analyze preclinical imaging studies and discuss their potential as neuroinflammation imaging agents. © 2008 Springer-Verlag.

AB - Neurodegenerative, inflammatory and neoplastic brain disorders involve neuroinflammatory reactions, and a biomarker of neuroinflammation would be useful for diagnostic, drug development and therapy control of these frequent diseases. In vivo imaging can document the expression of the peripheral benzodiazepine receptor (PBR)/translocator protein 18 kDa (TSPO) that is linked to microglial activation and considered a hallmark of neuroinflammation. The prototype positron emission tomography tracer for PBR, [11C]PK11195, has shown limitations that until now have slowed the clinical applications of PBR imaging. In recent years, dozens of new PET and SPECT radioligands for the PBR have been radiolabelled, and several have been evaluated in imaging protocols. Here we review the new PBR ligands proposed as challengers of [ 11C]PK11195, critically analyze preclinical imaging studies and discuss their potential as neuroinflammation imaging agents. © 2008 Springer-Verlag.

KW - [11C]PK11195

KW - Neuroinflammation

KW - Peripheral benzodiazepine receptor (PBR)

KW - PET

KW - Translocator protein 18kDa (TSPO)

U2 - 10.1007/s00259-008-0908-9

DO - 10.1007/s00259-008-0908-9

M3 - Article

C2 - 18828015

SN - 1619-7070

VL - 35

SP - 2304

EP - 2319

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 12

ER -

Nuclear imaging of neuroinflammation: A comprehensive review of [ 11C]PK11195 challengers

Abstract

Keywords

Access to Document

Fingerprint

Cite this