Nuclear magnetic resonance probing of binding interactions used by minor groove binding, DNA-directed ligands: Assignment of the binding site of Hoechst 33258 on the self-complementary oligonucleotide, d(CGCGAATTCGCG)

John A. Parkinson; Jill Barber; Kenneth T. Douglas; John Rosamund; Derek Sharples

doi:10.1039/C39890001023

Nuclear magnetic resonance probing of binding interactions used by minor groove binding, DNA-directed ligands: Assignment of the binding site of Hoechst 33258 on the self-complementary oligonucleotide, d(CGCGAATTCGCG)

John A. Parkinson^*, Jill Barber, Kenneth T. Douglas, John Rosamund, Derek Sharples

^*Corresponding author for this work

UMIST

Research output: Contribution to journal › Article › peer-review

Abstract

The binding of Hoechst 33258 to the minor groove of the duplex formed by the self-complementary oligonucleotide d(CGCGAATTCGCG) has been shown by means of high-field ¹H nuclear magnetic resonance spectroscopy to be across the central AATT region of the duplex.

Original language	English
Pages (from-to)	1023-1025
Number of pages	3
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	15
DOIs	https://doi.org/10.1039/C39890001023
Publication status	Published - 1989

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Parkinson, J. A., Barber, J., Douglas, K. T., Rosamund, J., & Sharples, D. (1989). Nuclear magnetic resonance probing of binding interactions used by minor groove binding, DNA-directed ligands: Assignment of the binding site of Hoechst 33258 on the self-complementary oligonucleotide, d(CGCGAATTCGCG). Journal of the Chemical Society, Chemical Communications, (15), 1023-1025. https://doi.org/10.1039/C39890001023

Parkinson, John A. ; Barber, Jill ; Douglas, Kenneth T. et al. / Nuclear magnetic resonance probing of binding interactions used by minor groove binding, DNA-directed ligands : Assignment of the binding site of Hoechst 33258 on the self-complementary oligonucleotide, d(CGCGAATTCGCG). In: Journal of the Chemical Society, Chemical Communications. 1989 ; No. 15. pp. 1023-1025.

@article{1afe3493a9f344b7ad8d0372e3c38069,

title = "Nuclear magnetic resonance probing of binding interactions used by minor groove binding, DNA-directed ligands: Assignment of the binding site of Hoechst 33258 on the self-complementary oligonucleotide, d(CGCGAATTCGCG)",

abstract = "The binding of Hoechst 33258 to the minor groove of the duplex formed by the self-complementary oligonucleotide d(CGCGAATTCGCG) has been shown by means of high-field 1H nuclear magnetic resonance spectroscopy to be across the central AATT region of the duplex.",

author = "Parkinson, \{John A.\} and Jill Barber and Douglas, \{Kenneth T.\} and John Rosamund and Derek Sharples",

year = "1989",

doi = "10.1039/C39890001023",

language = "English",

pages = "1023--1025",

journal = "Journal of the Chemical Society, Chemical Communications",

issn = "0022-4936",

publisher = "Chemical Society",

number = "15",

}

Parkinson, JA, Barber, J , Douglas, KT, Rosamund, J & Sharples, D 1989, 'Nuclear magnetic resonance probing of binding interactions used by minor groove binding, DNA-directed ligands: Assignment of the binding site of Hoechst 33258 on the self-complementary oligonucleotide, d(CGCGAATTCGCG)', Journal of the Chemical Society, Chemical Communications, no. 15, pp. 1023-1025. https://doi.org/10.1039/C39890001023

Nuclear magnetic resonance probing of binding interactions used by minor groove binding, DNA-directed ligands: Assignment of the binding site of Hoechst 33258 on the self-complementary oligonucleotide, d(CGCGAATTCGCG). / Parkinson, John A.; Barber, Jill ; Douglas, Kenneth T. et al.
In: Journal of the Chemical Society, Chemical Communications, No. 15, 1989, p. 1023-1025.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Nuclear magnetic resonance probing of binding interactions used by minor groove binding, DNA-directed ligands

T2 - Assignment of the binding site of Hoechst 33258 on the self-complementary oligonucleotide, d(CGCGAATTCGCG)

AU - Parkinson, John A.

AU - Barber, Jill

AU - Douglas, Kenneth T.

AU - Rosamund, John

AU - Sharples, Derek

PY - 1989

Y1 - 1989

N2 - The binding of Hoechst 33258 to the minor groove of the duplex formed by the self-complementary oligonucleotide d(CGCGAATTCGCG) has been shown by means of high-field 1H nuclear magnetic resonance spectroscopy to be across the central AATT region of the duplex.

AB - The binding of Hoechst 33258 to the minor groove of the duplex formed by the self-complementary oligonucleotide d(CGCGAATTCGCG) has been shown by means of high-field 1H nuclear magnetic resonance spectroscopy to be across the central AATT region of the duplex.

UR - https://www.scopus.com/pages/publications/37049089546

U2 - 10.1039/C39890001023

DO - 10.1039/C39890001023

M3 - Article

AN - SCOPUS:37049089546

SN - 0022-4936

SP - 1023

EP - 1025

JO - Journal of the Chemical Society, Chemical Communications

JF - Journal of the Chemical Society, Chemical Communications

IS - 15

ER -

Parkinson JA, Barber J , Douglas KT, Rosamund J, Sharples D. Nuclear magnetic resonance probing of binding interactions used by minor groove binding, DNA-directed ligands: Assignment of the binding site of Hoechst 33258 on the self-complementary oligonucleotide, d(CGCGAATTCGCG). Journal of the Chemical Society, Chemical Communications. 1989;(15):1023-1025. doi: 10.1039/C39890001023

Nuclear magnetic resonance probing of binding interactions used by minor groove binding, DNA-directed ligands: Assignment of the binding site of Hoechst 33258 on the self-complementary oligonucleotide, d(CGCGAATTCGCG)

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