Nuclear quantum tunnelling in enzymatic reactions - an enzymologist's perspective.

Linus Johannissen, Sam Hay, NS Scrutton

    Research output: Contribution to journalArticlepeer-review


    Enzyme-catalysed H-transfer reactions are ubiquitous, yet fundamental details of these reactions remain unresolved. In this perspective, we discuss the roles of nuclear quantum tunnelling and (compressive) dynamics during these reactions. Evidence for the coupling of specific substrate and/or protein vibrations to the chemical coordinate is considered and a case is made for the combination of multiple experimental and computational/theoretical approaches when studying these reactions.
    Original languageEnglish
    Pages (from-to)30775-30782
    Number of pages8
    JournalPhysical Chemistry Chemical Physics
    Issue number46
    Publication statusPublished - 18 Nov 2015


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