Nucleation control in solution mediated polymorphic phase transformations: The case of 2,6-dihydroxybenzoic acid

R. J. Davey; N. Blagden; S. Righini; H. Alison; E. S. Ferrari

doi:10.1021/jp013044i

Nucleation control in solution mediated polymorphic phase transformations: The case of 2,6-dihydroxybenzoic acid

R. J. Davey, N. Blagden, S. Righini, H. Alison, E. S. Ferrari

Research output: Contribution to journal › Article › peer-review

Abstract

This contribution describes the kinetics of the solution mediated phase transformation between forms 1 and 2 of dihydroxybenzoic acid. It is shown how a combination of kinetic, morphological, and modeling data can be used to give a full description of the rate-determining process in such a transformation. Surprisingly, secondary nucleation is found to dominate the kinetic processes. Such a phenomenon is well-known in continuous crystallization but is reported here for the first time in a polymorphic phase transformation. This observation has significant consequences for process and product control in the pharmaceutical and specialty chemicals industries.

Original language	English
Pages (from-to)	1954-1959
Number of pages	5
Journal	Journal of Physical Chemistry B
Volume	106
Issue number	8
DOIs	https://doi.org/10.1021/jp013044i
Publication status	Published - 28 Feb 2002

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abstract = "This contribution describes the kinetics of the solution mediated phase transformation between forms 1 and 2 of dihydroxybenzoic acid. It is shown how a combination of kinetic, morphological, and modeling data can be used to give a full description of the rate-determining process in such a transformation. Surprisingly, secondary nucleation is found to dominate the kinetic processes. Such a phenomenon is well-known in continuous crystallization but is reported here for the first time in a polymorphic phase transformation. This observation has significant consequences for process and product control in the pharmaceutical and specialty chemicals industries.",

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AU - Davey, R. J.

AU - Blagden, N.

AU - Righini, S.

AU - Alison, H.

AU - Ferrari, E. S.

PY - 2002/2/28

Y1 - 2002/2/28

N2 - This contribution describes the kinetics of the solution mediated phase transformation between forms 1 and 2 of dihydroxybenzoic acid. It is shown how a combination of kinetic, morphological, and modeling data can be used to give a full description of the rate-determining process in such a transformation. Surprisingly, secondary nucleation is found to dominate the kinetic processes. Such a phenomenon is well-known in continuous crystallization but is reported here for the first time in a polymorphic phase transformation. This observation has significant consequences for process and product control in the pharmaceutical and specialty chemicals industries.

AB - This contribution describes the kinetics of the solution mediated phase transformation between forms 1 and 2 of dihydroxybenzoic acid. It is shown how a combination of kinetic, morphological, and modeling data can be used to give a full description of the rate-determining process in such a transformation. Surprisingly, secondary nucleation is found to dominate the kinetic processes. Such a phenomenon is well-known in continuous crystallization but is reported here for the first time in a polymorphic phase transformation. This observation has significant consequences for process and product control in the pharmaceutical and specialty chemicals industries.

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DO - 10.1021/jp013044i

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JO - Journal of Physical Chemistry B

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IS - 8

ER -

Nucleation control in solution mediated polymorphic phase transformations: The case of 2,6-dihydroxybenzoic acid

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