Nutrient restriction and radiation therapy for cancer treatment: When less is more

Colin E. Champ, Renato Baserga, Mark V. Mishra, Lianjin Jin, Federica Sotgia, Michael P. Lisanti, Richard G. Pestell, Adam P. Dicker, Nicole L. Simone

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Calorie restriction (CR), or a diet modification aiming to reduce the total intake of calories by 20%-40%, has been shown to increase longevity across multiple species. Recently, there has been growing interest in investigating the potential role of CR as a treatment intervention for age-related diseases, such as cancer, because an increasing body of literature has demonstrated a metabolic component to both carcinogenesis and tumor progression. In fact, many of the molecular pathways that are altered with CR are also known to be altered in cancer. Therefore, manipulation of these pathways using CR can render cancer cells, and most notably breast cancer cells, more susceptible to standard cytotoxic treatment with radiation and chemotherapy. In this review article we demonstrate the laboratory and clinical evidence that exists for CR and show compelling evidence through the molecular pathways CR induces about how it may be used as a treatment in tandem with radiation therapy to improve our rates of disease control. © AlphaMed Press.
    Original languageEnglish
    Pages (from-to)97-103
    Number of pages6
    JournalOncologist
    Volume18
    Issue number1
    DOIs
    Publication statusPublished - 2013

    Keywords

    • Calorie restriction
    • Cancer
    • Intermittent fasting
    • Radiotherapy

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