Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort

F. Zaccardi; C. Razieh; C.L. Gillies; Y. Chudasama; A.B. Docherty; P.J.M. Openshaw; J.K. Baillie; M.G. Semple; K. Khunti; G. Carson; B. Alex; B. Bach; W.S. Barclay; D. Bogaert; M. Chand; A. da Silva Filipe; J.A. Hiscox; P.W. Horby; S. Ijaz; S. Khoo; P. Klenerman; W.S. Lim; A.J. Mentzer; L. Merson; A.M. Meynert; M. Noursadeghi; M. Palmarini; W.A. Paxton; G. Pollakis; A. Rambaut; V. Sancho-Shimizu; L. Sigfrid; T. Solomon; S. Sriskandan; D. Stuart; R.S. Tedder; R.S. Thwaites; L.C.W. Turtle; M. Zambon; C. Donohue; J. Ewins; W. Oosthuyzen; F. Griffiths; R. Pius; T.M. Drake; C.J. Fairfield; M. Girvan; E. Saviciute; M. Connor; S. Halpin; R. Hendry; J. Scott-Brown; W. Greenhalf; V. Shaw; I.G. Asiimwe; S. Bakshi; K. Bullock; B.W.A. Catterall; O. Dincarslan; C. Dunn; I. Garcia-Dorival; W. Greenhalf; P. Gunning; R.L. Jensen; S. Khandaker; R.T. Kiy; C. Koukorava; A. Lake; S. Lant; D. Latawiec; L. Lavelle-Langham; D. Lefteri; L. Lett; L.A. Livoti; M. Mancini; J. McLauchlan; S. Metelmann; N.S. Miah; R. Penrice-Randal; J. Pilgrim; W. Reynolds; P.M. Ridley; D. Sales; V.E. Shaw; K.S. Subramaniam; A. Szemiel; A. Taggart; E. Trochu; L. van Tonder; K. Adeniji; D. Agranoff; K. Agwuh; D. Ail; A. Alegria; B. Angus; A. Ashish; S. Bari; G. Barlow; S. Barnass; N. Barrett; C. Bassford; M. Beadsworth; J. Bernatoniene; J. Berridge; N. Best; P. Bothma; D. Brealey; R. Brittain-Long; N. Bulteel; T. Burden; A. Burtenshaw; V. Caruth; D. Chambler; N. Chee; S. Chukkambotla; P. Collini; C. Cosgrove; J. Cupitt; M.-T. Cutino-Moguel; P. Dark; S. Dervisevic; P. Donnison; S. Douthwaite; I. DuRand; A. Dushianthan; T. Dyer; C. Eziefula; C. Fegan; A. Finn; J. Godden; A. Goldsmith; E. Hardy; P. Havalda; D.B. Hawcutt; M. Hobrok; A. Holme; A. Hormis; A. Kaliappan; V. Kasipandian; S. Kegg; M. Kelsey; C. Kerrison; I. Kerslake; O. Koch; G. Koduri; G. Koshy; T. Leiner; P. Lillie; J. Limb; V. Linnett; M. MacMahon; E. MacNaughton; R. Mankregod; H. Masson; E. Matovu; K. McCullough; R. McEwen; M. Meda; J. Minton; M. Mirfenderesky; K. Mohandas; Q. Mok; K. Mortimore; S. Moses; M. Mpenge; T. Nagarajan; I. Otahal; M. Pais; S. Panchatsharam; H. Paraiso; J. Pepperell; M. Peters; M. Phull; S. Pintus; J.S. Pooni; F. Post; R. Prout; N. Rae; H. Reschreiter; T. Reynolds; N. Richardson; G. Rousseau; T. Saluja; P. Shanmuga; J. Sizer; C. Snelson; N. Spittle; N. Staines; T. Stambach; P. Subudhi; T. Szakmany; K. Tatham; A. Tridente; D. Tupper-Carey; M. Twagira; N. Vallotton; L. Vincent-Smith; S. Visuvanathan; A. Vuylsteke; S. Waddy; R. Wake; I. Welters; T. Whitehouse; M. Wijesinghe; S. Winchester; M. Wiselka; A. Wolverson; D.G. Wooton; B. Yates

doi:10.1002/oby.23178

Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort

F. Zaccardi, C. Razieh, C.L. Gillies, Y. Chudasama, A.B. Docherty, P.J.M. Openshaw, J.K. Baillie, M.G. Semple, K. Khunti, G. Carson, B. Alex, B. Bach, W.S. Barclay, D. Bogaert, M. Chand, A. da Silva Filipe, J.A. Hiscox, P.W. Horby, S. Ijaz, S. KhooP. Klenerman, W.S. Lim, A.J. Mentzer, L. Merson, A.M. Meynert, M. Noursadeghi, M. Palmarini, W.A. Paxton, G. Pollakis, A. Rambaut, V. Sancho-Shimizu, L. Sigfrid, T. Solomon, S. Sriskandan, D. Stuart, R.S. Tedder, R.S. Thwaites, L.C.W. Turtle, M. Zambon, C. Donohue, J. Ewins, W. Oosthuyzen, F. Griffiths, R. Pius, T.M. Drake, C.J. Fairfield, M. Girvan, E. Saviciute, M. Connor, S. Halpin, R. Hendry, J. Scott-Brown, W. Greenhalf, V. Shaw, I.G. Asiimwe, S. Bakshi, K. Bullock, B.W.A. Catterall, O. Dincarslan, C. Dunn, I. Garcia-Dorival, W. Greenhalf, P. Gunning, R.L. Jensen, S. Khandaker, R.T. Kiy, C. Koukorava, A. Lake, S. Lant, D. Latawiec, L. Lavelle-Langham, D. Lefteri, L. Lett, L.A. Livoti, M. Mancini, J. McLauchlan, S. Metelmann, N.S. Miah, R. Penrice-Randal, J. Pilgrim, W. Reynolds, P.M. Ridley, D. Sales, V.E. Shaw, K.S. Subramaniam, A. Szemiel, A. Taggart, E. Trochu, L. van Tonder, K. Adeniji, D. Agranoff, K. Agwuh, D. Ail, A. Alegria, B. Angus, A. Ashish, S. Bari, G. Barlow, S. Barnass, N. Barrett, C. Bassford, M. Beadsworth, J. Bernatoniene, J. Berridge, N. Best, P. Bothma, D. Brealey, R. Brittain-Long, N. Bulteel, T. Burden, A. Burtenshaw, V. Caruth, D. Chambler, N. Chee, S. Chukkambotla, P. Collini, C. Cosgrove, J. Cupitt, M.-T. Cutino-Moguel, P. Dark, S. Dervisevic, P. Donnison, S. Douthwaite, I. DuRand, A. Dushianthan, T. Dyer, C. Eziefula, C. Fegan, A. Finn, J. Godden, A. Goldsmith, E. Hardy, P. Havalda, D.B. Hawcutt, M. Hobrok, A. Holme, A. Hormis, A. Kaliappan, V. Kasipandian, S. Kegg, M. Kelsey, C. Kerrison, I. Kerslake, O. Koch, G. Koduri, G. Koshy, T. Leiner, P. Lillie, J. Limb, V. Linnett, M. MacMahon, E. MacNaughton, R. Mankregod, H. Masson, E. Matovu, K. McCullough, R. McEwen, M. Meda, J. Minton, M. Mirfenderesky, K. Mohandas, Q. Mok, K. Mortimore, S. Moses, M. Mpenge, T. Nagarajan, I. Otahal, M. Pais, S. Panchatsharam, H. Paraiso, J. Pepperell, M. Peters, M. Phull, S. Pintus, J.S. Pooni, F. Post, R. Prout, N. Rae, H. Reschreiter, T. Reynolds, N. Richardson, G. Rousseau, T. Saluja, P. Shanmuga, J. Sizer, C. Snelson, N. Spittle, N. Staines, T. Stambach, P. Subudhi, T. Szakmany, K. Tatham, A. Tridente, D. Tupper-Carey, M. Twagira, N. Vallotton, L. Vincent-Smith, S. Visuvanathan, A. Vuylsteke, S. Waddy, R. Wake, I. Welters, T. Whitehouse, M. Wijesinghe, S. Winchester, M. Wiselka, A. Wolverson, D.G. Wooton, B. Yates

Division of Immunology, Immunity to Infection and Respiratory Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

Objective: The aim of this study was to investigate the association of obesity with in-hospital coronavirus disease 2019 (COVID-19) outcomes in different ethnic groups. Methods: Patients admitted to hospital with COVID-19 in the United Kingdom through the Clinical Characterisation Protocol UK (CCP-UK) developed by the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) were included from February 6 to October 12, 2020. Ethnicity was classified as White, South Asian, Black, and other minority ethnic groups. Outcomes were admission to critical care, mechanical ventilation, and in-hospital mortality, adjusted for age, sex, and chronic diseases. Results: Of the participants included, 54,254 (age = 76 years; 45.0% women) were White, 3,728 (57 years; 41.1% women) were South Asian, 2,523 (58 years; 44.9% women) were Black, and 5,427 (61 years; 40.8% women) were other ethnicities. Obesity was associated with all outcomes in all ethnic groups, with associations strongest for black ethnicities. When stratified by ethnicity and obesity status, the odds ratios for admission to critical care, mechanical ventilation, and mortality in black ethnicities with obesity were 3.91 (3.13-4.88), 5.03 (3.94-6.63), and 1.93 (1.49-2.51), respectively, compared with White ethnicities without obesity. Conclusions: Obesity was associated with an elevated risk of in-hospital COVID-19 outcomes in all ethnic groups, with associations strongest in Black ethnicities.

Original language	English
Pages (from-to)	1223-1230
Number of pages	8
Journal	Obesity
Volume	29
Issue number	7
Early online date	14 May 2021
DOIs	https://doi.org/10.1002/oby.23178
Publication status	Published - 1 Jul 2021

Keywords

Adult
Aged
COVID-19/ethnology
Cohort Studies
Comorbidity
Critical Care/statistics & numerical data
Ethnicity/statistics & numerical data
Female
Hospital Mortality
Hospitalization/statistics & numerical data
Humans
Male
Middle Aged
Minority Groups/statistics & numerical data
Obesity/ethnology
Odds Ratio
Respiration, Artificial/statistics & numerical data
United Kingdom
Young Adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/oby.23178

Obesity - 2021 - Yates - Obesity Ethnicity and Risk of Critical Care Mechanical Ventilation and Mortality in PatientsFinal published version, 707 KBLicence: CC BY

Cite this

Zaccardi, F., Razieh, C., Gillies, C. L., Chudasama, Y., Docherty, A. B., Openshaw, P. J. M., Baillie, J. K., Semple, M. G., Khunti, K., Carson, G., Alex, B., Bach, B., Barclay, W. S., Bogaert, D., Chand, M., da Silva Filipe, A., Hiscox, J. A., Horby, P. W., Ijaz, S., ... Yates, B. (2021). Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort. Obesity, 29(7), 1223-1230. https://doi.org/10.1002/oby.23178

@article{01dff02608794911b019f696b49e60a7,

title = "Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort",

abstract = "Objective: The aim of this study was to investigate the association of obesity with in-hospital coronavirus disease 2019 (COVID-19) outcomes in different ethnic groups. Methods: Patients admitted to hospital with COVID-19 in the United Kingdom through the Clinical Characterisation Protocol UK (CCP-UK) developed by the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) were included from February 6 to October 12, 2020. Ethnicity was classified as White, South Asian, Black, and other minority ethnic groups. Outcomes were admission to critical care, mechanical ventilation, and in-hospital mortality, adjusted for age, sex, and chronic diseases. Results: Of the participants included, 54,254 (age = 76 years; 45.0% women) were White, 3,728 (57 years; 41.1% women) were South Asian, 2,523 (58 years; 44.9% women) were Black, and 5,427 (61 years; 40.8% women) were other ethnicities. Obesity was associated with all outcomes in all ethnic groups, with associations strongest for black ethnicities. When stratified by ethnicity and obesity status, the odds ratios for admission to critical care, mechanical ventilation, and mortality in black ethnicities with obesity were 3.91 (3.13-4.88), 5.03 (3.94-6.63), and 1.93 (1.49-2.51), respectively, compared with White ethnicities without obesity. Conclusions: Obesity was associated with an elevated risk of in-hospital COVID-19 outcomes in all ethnic groups, with associations strongest in Black ethnicities.",

keywords = "Adult, Aged, COVID-19/ethnology, Cohort Studies, Comorbidity, Critical Care/statistics & numerical data, Ethnicity/statistics & numerical data, Female, Hospital Mortality, Hospitalization/statistics & numerical data, Humans, Male, Middle Aged, Minority Groups/statistics & numerical data, Obesity/ethnology, Odds Ratio, Respiration, Artificial/statistics & numerical data, United Kingdom, Young Adult",

author = "F. Zaccardi and C. Razieh and C.L. Gillies and Y. Chudasama and A.B. Docherty and P.J.M. Openshaw and J.K. Baillie and M.G. Semple and K. Khunti and G. Carson and B. Alex and B. Bach and W.S. Barclay and D. Bogaert and M. Chand and {da Silva Filipe}, A. and J.A. Hiscox and P.W. Horby and S. Ijaz and S. Khoo and P. Klenerman and W.S. Lim and A.J. Mentzer and L. Merson and A.M. Meynert and M. Noursadeghi and M. Palmarini and W.A. Paxton and G. Pollakis and A. Rambaut and V. Sancho-Shimizu and L. Sigfrid and T. Solomon and S. Sriskandan and D. Stuart and R.S. Tedder and R.S. Thwaites and L.C.W. Turtle and M. Zambon and C. Donohue and J. Ewins and W. Oosthuyzen and F. Griffiths and R. Pius and T.M. Drake and C.J. Fairfield and M. Girvan and E. Saviciute and M. Connor and S. Halpin and R. Hendry and J. Scott-Brown and W. Greenhalf and V. Shaw and I.G. Asiimwe and S. Bakshi and K. Bullock and B.W.A. Catterall and O. Dincarslan and C. Dunn and I. Garcia-Dorival and W. Greenhalf and P. Gunning and R.L. Jensen and S. Khandaker and R.T. Kiy and C. Koukorava and A. Lake and S. Lant and D. Latawiec and L. Lavelle-Langham and D. Lefteri and L. Lett and L.A. Livoti and M. Mancini and J. McLauchlan and S. Metelmann and N.S. Miah and R. Penrice-Randal and J. Pilgrim and W. Reynolds and P.M. Ridley and D. Sales and V.E. Shaw and K.S. Subramaniam and A. Szemiel and A. Taggart and E. Trochu and {van Tonder}, L. and K. Adeniji and D. Agranoff and K. Agwuh and D. Ail and A. Alegria and B. Angus and A. Ashish and S. Bari and G. Barlow and S. Barnass and N. Barrett and C. Bassford and M. Beadsworth and J. Bernatoniene and J. Berridge and N. Best and P. Bothma and D. Brealey and R. Brittain-Long and N. Bulteel and T. Burden and A. Burtenshaw and V. Caruth and D. Chambler and N. Chee and S. Chukkambotla and P. Collini and C. Cosgrove and J. Cupitt and M.-T. Cutino-Moguel and P. Dark and S. Dervisevic and P. Donnison and S. Douthwaite and I. DuRand and A. Dushianthan and T. Dyer and C. Eziefula and C. Fegan and A. Finn and J. Godden and A. Goldsmith and E. Hardy and P. Havalda and D.B. Hawcutt and M. Hobrok and A. Holme and A. Hormis and A. Kaliappan and V. Kasipandian and S. Kegg and M. Kelsey and C. Kerrison and I. Kerslake and O. Koch and G. Koduri and G. Koshy and T. Leiner and P. Lillie and J. Limb and V. Linnett and M. MacMahon and E. MacNaughton and R. Mankregod and H. Masson and E. Matovu and K. McCullough and R. McEwen and M. Meda and J. Minton and M. Mirfenderesky and K. Mohandas and Q. Mok and K. Mortimore and S. Moses and M. Mpenge and T. Nagarajan and I. Otahal and M. Pais and S. Panchatsharam and H. Paraiso and J. Pepperell and M. Peters and M. Phull and S. Pintus and J.S. Pooni and F. Post and R. Prout and N. Rae and H. Reschreiter and T. Reynolds and N. Richardson and G. Rousseau and T. Saluja and P. Shanmuga and J. Sizer and C. Snelson and N. Spittle and N. Staines and T. Stambach and P. Subudhi and T. Szakmany and K. Tatham and A. Tridente and D. Tupper-Carey and M. Twagira and N. Vallotton and L. Vincent-Smith and S. Visuvanathan and A. Vuylsteke and S. Waddy and R. Wake and I. Welters and T. Whitehouse and M. Wijesinghe and S. Winchester and M. Wiselka and A. Wolverson and D.G. Wooton and B. Yates",

note = "Funding Information: This work was supported by the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre (BRC), NIHR Applied Research Collaboration East Midlands (ARC EM), and a grant from the UK Research and Innovation ‐ Department of Health and Social Care (UKRI‐DHSC) COVID‐19 Rapid Response Rolling Call (MR/V020536/1 to TY); NIHR (award CO‐CIN‐01 to MGS); the Medical Research Council (MRC; grant MC_PC_19059 to MGS); and by the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool. The funder/sponsor had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Funding Information: KK is supported by the NIHR ARC EM and TY by the NIHR BRC. KK is Director for the University of Leicester Centre for Black and Minority Ethnic Health, trustee of the South Asian Health Foundation, national NIHR ARC lead for Ethnicity and Diversity, and a member of the Independent Scientific Advisory Group for Emergencies (SAGE) and Chair of the SAGE subgroup on ethnicity and COVID‐19. MGS is a member of SAGE COVID‐19. MGS reports grants from DHSC NIHR UK, grants from MRC UK, grants from HPRU in Emerging and Zoonotic Infections, University of Liverpool, during the conduct of the study, and other support from Integrum Scientific LLC, Greensboro, North Carolina, outside the submitted work. The other authors declared no conflict of interest. Publisher Copyright: {\textcopyright} 2021 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS).",

year = "2021",

month = jul,

day = "1",

doi = "10.1002/oby.23178",

language = "English",

volume = "29",

pages = "1223--1230",

journal = "Obesity",

issn = "1930-7381",

publisher = "John Wiley & Sons Ltd",

number = "7",

}

Zaccardi, F, Razieh, C, Gillies, CL, Chudasama, Y, Docherty, AB, Openshaw, PJM, Baillie, JK, Semple, MG, Khunti, K, Carson, G, Alex, B, Bach, B, Barclay, WS, Bogaert, D, Chand, M, da Silva Filipe, A, Hiscox, JA, Horby, PW, Ijaz, S, Khoo, S, Klenerman, P, Lim, WS, Mentzer, AJ, Merson, L, Meynert, AM, Noursadeghi, M, Palmarini, M, Paxton, WA, Pollakis, G, Rambaut, A, Sancho-Shimizu, V, Sigfrid, L, Solomon, T, Sriskandan, S, Stuart, D, Tedder, RS, Thwaites, RS, Turtle, LCW, Zambon, M, Donohue, C, Ewins, J, Oosthuyzen, W, Griffiths, F, Pius, R, Drake, TM, Fairfield, CJ, Girvan, M, Saviciute, E, Connor, M, Halpin, S, Hendry, R, Scott-Brown, J, Greenhalf, W, Shaw, V, Asiimwe, IG, Bakshi, S, Bullock, K, Catterall, BWA, Dincarslan, O, Dunn, C, Garcia-Dorival, I, Greenhalf, W, Gunning, P, Jensen, RL, Khandaker, S, Kiy, RT, Koukorava, C, Lake, A, Lant, S, Latawiec, D, Lavelle-Langham, L, Lefteri, D, Lett, L, Livoti, LA, Mancini, M, McLauchlan, J, Metelmann, S, Miah, NS, Penrice-Randal, R, Pilgrim, J, Reynolds, W, Ridley, PM, Sales, D, Shaw, VE, Subramaniam, KS, Szemiel, A, Taggart, A, Trochu, E, van Tonder, L, Adeniji, K, Agranoff, D, Agwuh, K, Ail, D, Alegria, A, Angus, B, Ashish, A, Bari, S, Barlow, G, Barnass, S, Barrett, N, Bassford, C, Beadsworth, M, Bernatoniene, J, Berridge, J, Best, N, Bothma, P, Brealey, D, Brittain-Long, R, Bulteel, N, Burden, T, Burtenshaw, A, Caruth, V, Chambler, D, Chee, N, Chukkambotla, S, Collini, P, Cosgrove, C, Cupitt, J, Cutino-Moguel, M-T, Dark, P, Dervisevic, S, Donnison, P, Douthwaite, S, DuRand, I, Dushianthan, A, Dyer, T, Eziefula, C, Fegan, C, Finn, A, Godden, J, Goldsmith, A, Hardy, E, Havalda, P, Hawcutt, DB, Hobrok, M, Holme, A, Hormis, A, Kaliappan, A, Kasipandian, V, Kegg, S, Kelsey, M, Kerrison, C, Kerslake, I, Koch, O, Koduri, G, Koshy, G, Leiner, T, Lillie, P, Limb, J, Linnett, V, MacMahon, M, MacNaughton, E, Mankregod, R, Masson, H, Matovu, E, McCullough, K, McEwen, R, Meda, M, Minton, J, Mirfenderesky, M, Mohandas, K, Mok, Q, Mortimore, K, Moses, S, Mpenge, M, Nagarajan, T, Otahal, I, Pais, M, Panchatsharam, S, Paraiso, H, Pepperell, J, Peters, M, Phull, M, Pintus, S, Pooni, JS, Post, F, Prout, R, Rae, N, Reschreiter, H, Reynolds, T, Richardson, N, Rousseau, G, Saluja, T, Shanmuga, P, Sizer, J, Snelson, C, Spittle, N, Staines, N, Stambach, T, Subudhi, P, Szakmany, T, Tatham, K, Tridente, A, Tupper-Carey, D, Twagira, M, Vallotton, N, Vincent-Smith, L, Visuvanathan, S, Vuylsteke, A, Waddy, S, Wake, R, Welters, I, Whitehouse, T, Wijesinghe, M, Winchester, S, Wiselka, M, Wolverson, A, Wooton, DG & Yates, B 2021, 'Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort', Obesity, vol. 29, no. 7, pp. 1223-1230. https://doi.org/10.1002/oby.23178

TY - JOUR

T1 - Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort

AU - Zaccardi, F.

AU - Razieh, C.

AU - Gillies, C.L.

AU - Chudasama, Y.

AU - Docherty, A.B.

AU - Openshaw, P.J.M.

AU - Baillie, J.K.

AU - Semple, M.G.

AU - Khunti, K.

AU - Carson, G.

AU - Alex, B.

AU - Bach, B.

AU - Barclay, W.S.

AU - Bogaert, D.

AU - Chand, M.

AU - da Silva Filipe, A.

AU - Hiscox, J.A.

AU - Horby, P.W.

AU - Ijaz, S.

AU - Khoo, S.

AU - Klenerman, P.

AU - Lim, W.S.

AU - Mentzer, A.J.

AU - Merson, L.

AU - Meynert, A.M.

AU - Noursadeghi, M.

AU - Palmarini, M.

AU - Paxton, W.A.

AU - Pollakis, G.

AU - Rambaut, A.

AU - Sancho-Shimizu, V.

AU - Sigfrid, L.

AU - Solomon, T.

AU - Sriskandan, S.

AU - Stuart, D.

AU - Tedder, R.S.

AU - Thwaites, R.S.

AU - Turtle, L.C.W.

AU - Zambon, M.

AU - Donohue, C.

AU - Ewins, J.

AU - Oosthuyzen, W.

AU - Griffiths, F.

AU - Pius, R.

AU - Drake, T.M.

AU - Fairfield, C.J.

AU - Girvan, M.

AU - Saviciute, E.

AU - Connor, M.

AU - Halpin, S.

AU - Hendry, R.

AU - Scott-Brown, J.

AU - Greenhalf, W.

AU - Shaw, V.

AU - Asiimwe, I.G.

AU - Bakshi, S.

AU - Bullock, K.

AU - Catterall, B.W.A.

AU - Dincarslan, O.

AU - Dunn, C.

AU - Garcia-Dorival, I.

AU - Greenhalf, W.

AU - Gunning, P.

AU - Jensen, R.L.

AU - Khandaker, S.

AU - Kiy, R.T.

AU - Koukorava, C.

AU - Lake, A.

AU - Lant, S.

AU - Latawiec, D.

AU - Lavelle-Langham, L.

AU - Lefteri, D.

AU - Lett, L.

AU - Livoti, L.A.

AU - Mancini, M.

AU - McLauchlan, J.

AU - Metelmann, S.

AU - Miah, N.S.

AU - Penrice-Randal, R.

AU - Pilgrim, J.

AU - Reynolds, W.

AU - Ridley, P.M.

AU - Sales, D.

AU - Shaw, V.E.

AU - Subramaniam, K.S.

AU - Szemiel, A.

AU - Taggart, A.

AU - Trochu, E.

AU - van Tonder, L.

AU - Adeniji, K.

AU - Agranoff, D.

AU - Agwuh, K.

AU - Ail, D.

AU - Alegria, A.

AU - Angus, B.

AU - Ashish, A.

AU - Bari, S.

AU - Barlow, G.

AU - Barnass, S.

AU - Barrett, N.

AU - Bassford, C.

AU - Beadsworth, M.

AU - Bernatoniene, J.

AU - Berridge, J.

AU - Best, N.

AU - Bothma, P.

AU - Brealey, D.

AU - Brittain-Long, R.

AU - Bulteel, N.

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N1 - Funding Information: This work was supported by the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre (BRC), NIHR Applied Research Collaboration East Midlands (ARC EM), and a grant from the UK Research and Innovation ‐ Department of Health and Social Care (UKRI‐DHSC) COVID‐19 Rapid Response Rolling Call (MR/V020536/1 to TY); NIHR (award CO‐CIN‐01 to MGS); the Medical Research Council (MRC; grant MC_PC_19059 to MGS); and by the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool. The funder/sponsor had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Funding Information: KK is supported by the NIHR ARC EM and TY by the NIHR BRC. KK is Director for the University of Leicester Centre for Black and Minority Ethnic Health, trustee of the South Asian Health Foundation, national NIHR ARC lead for Ethnicity and Diversity, and a member of the Independent Scientific Advisory Group for Emergencies (SAGE) and Chair of the SAGE subgroup on ethnicity and COVID‐19. MGS is a member of SAGE COVID‐19. MGS reports grants from DHSC NIHR UK, grants from MRC UK, grants from HPRU in Emerging and Zoonotic Infections, University of Liverpool, during the conduct of the study, and other support from Integrum Scientific LLC, Greensboro, North Carolina, outside the submitted work. The other authors declared no conflict of interest. Publisher Copyright: © 2021 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS).

PY - 2021/7/1

Y1 - 2021/7/1

N2 - Objective: The aim of this study was to investigate the association of obesity with in-hospital coronavirus disease 2019 (COVID-19) outcomes in different ethnic groups. Methods: Patients admitted to hospital with COVID-19 in the United Kingdom through the Clinical Characterisation Protocol UK (CCP-UK) developed by the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) were included from February 6 to October 12, 2020. Ethnicity was classified as White, South Asian, Black, and other minority ethnic groups. Outcomes were admission to critical care, mechanical ventilation, and in-hospital mortality, adjusted for age, sex, and chronic diseases. Results: Of the participants included, 54,254 (age = 76 years; 45.0% women) were White, 3,728 (57 years; 41.1% women) were South Asian, 2,523 (58 years; 44.9% women) were Black, and 5,427 (61 years; 40.8% women) were other ethnicities. Obesity was associated with all outcomes in all ethnic groups, with associations strongest for black ethnicities. When stratified by ethnicity and obesity status, the odds ratios for admission to critical care, mechanical ventilation, and mortality in black ethnicities with obesity were 3.91 (3.13-4.88), 5.03 (3.94-6.63), and 1.93 (1.49-2.51), respectively, compared with White ethnicities without obesity. Conclusions: Obesity was associated with an elevated risk of in-hospital COVID-19 outcomes in all ethnic groups, with associations strongest in Black ethnicities.

AB - Objective: The aim of this study was to investigate the association of obesity with in-hospital coronavirus disease 2019 (COVID-19) outcomes in different ethnic groups. Methods: Patients admitted to hospital with COVID-19 in the United Kingdom through the Clinical Characterisation Protocol UK (CCP-UK) developed by the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) were included from February 6 to October 12, 2020. Ethnicity was classified as White, South Asian, Black, and other minority ethnic groups. Outcomes were admission to critical care, mechanical ventilation, and in-hospital mortality, adjusted for age, sex, and chronic diseases. Results: Of the participants included, 54,254 (age = 76 years; 45.0% women) were White, 3,728 (57 years; 41.1% women) were South Asian, 2,523 (58 years; 44.9% women) were Black, and 5,427 (61 years; 40.8% women) were other ethnicities. Obesity was associated with all outcomes in all ethnic groups, with associations strongest for black ethnicities. When stratified by ethnicity and obesity status, the odds ratios for admission to critical care, mechanical ventilation, and mortality in black ethnicities with obesity were 3.91 (3.13-4.88), 5.03 (3.94-6.63), and 1.93 (1.49-2.51), respectively, compared with White ethnicities without obesity. Conclusions: Obesity was associated with an elevated risk of in-hospital COVID-19 outcomes in all ethnic groups, with associations strongest in Black ethnicities.

KW - Adult

KW - Aged

KW - COVID-19/ethnology

KW - Cohort Studies

KW - Comorbidity

KW - Critical Care/statistics & numerical data

KW - Ethnicity/statistics & numerical data

KW - Female

KW - Hospital Mortality

KW - Hospitalization/statistics & numerical data

KW - Humans

KW - Male

KW - Middle Aged

KW - Minority Groups/statistics & numerical data

KW - Obesity/ethnology

KW - Odds Ratio

KW - Respiration, Artificial/statistics & numerical data

KW - United Kingdom

KW - Young Adult

U2 - 10.1002/oby.23178

DO - 10.1002/oby.23178

M3 - Article

C2 - 33755331

SN - 1930-7381

VL - 29

SP - 1223

EP - 1230

JO - Obesity

JF - Obesity

IS - 7

ER -

Obesity, Ethnicity, and Risk of Critical Care, Mechanical Ventilation, and Mortality in Patients Admitted to Hospital with COVID-19: Analysis of the ISARIC CCP-UK Cohort

Abstract

Keywords

UN SDGs

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