Objective measurement of contrast sensitivity and visual acuity with the steady-state visual evoked potential.

Since the appearance of Campbell and Maffei's and Harter and White's reports it has been well established that the visual evoked potential (VEP) can be used to predict psychophysical contrast sensitivity and visual acuity and is thus suited as an objective technique to assess these fundamental aspects of vision. Nevertheless, the technique has not become a standard diagnostic tool, being too time-consuming to apply and suffering from variable reliability under pathological visual conditions. In addition, there are problems of reliability in normal subjects. By using an unconventional stimulus--temporally sinusoidal 16-Hz on-off modulation of sinewave gratings--we demonstrated that these problems can be alleviated in normal subjects. This stimulus avoids the low signals in the visible range that frequently occur with conventional pattern-reversal stimuli, it leads to high correspondence between normal observers, and it is much faster to apply than are transient VEPs. Initial applications of this stimulus to amblyopes yielded promising results. The steady-state VEP could consequently turn into a viable diagnostic procedure in disturbances of visual contrast perception.