Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study

L Costas; C Infante-Rivard; J-P Zock; M Van Tongeren; P Boffetta; A Cusson; C Robles; D Casabonne; Y Benavente; N Becker; P Brennan; L Foretova; M Maynadié; A Staines; A Nieters; P Cocco; S de Sanjosé

doi:10.1038/bjc.2015.83

Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study

L Costas, C Infante-Rivard, J-P Zock, M Van Tongeren, P Boffetta, A Cusson, C Robles, D Casabonne, Y Benavente, N Becker, P Brennan, L Foretova, M Maynadié, A Staines, A Nieters, P Cocco, S de Sanjosé

Division of Population Health, Health Services Research & Primary Care (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma.

METHODS: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study.

RESULTS: Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend=0.02). Associations were observed among men, but not women.

CONCLUSIONS: Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes.

Original language	English
Pages (from-to)	1251-1256
Number of pages	6
Journal	British Journal of Cancer
Volume	112
Issue number	7
DOIs	https://doi.org/10.1038/bjc.2015.83
Publication status	Published - 31 Mar 2015

Keywords

Case-Control Studies
Endocrine Disruptors
Europe
Female
Humans
Incidence
Lymphoma
Male
Occupational Diseases
Occupational Exposure
Risk Factors
Sex Factors
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Costas, L., Infante-Rivard, C., Zock, J.-P., Van Tongeren, M., Boffetta, P., Cusson, A., Robles, C., Casabonne, D., Benavente, Y., Becker, N., Brennan, P., Foretova, L., Maynadié, M., Staines, A., Nieters, A., Cocco, P., & de Sanjosé, S. (2015). Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study. British Journal of Cancer, 112(7), 1251-1256. https://doi.org/10.1038/bjc.2015.83

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title = "Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study",

abstract = "BACKGROUND: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma.METHODS: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study.RESULTS: Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend=0.02). Associations were observed among men, but not women.CONCLUSIONS: Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes.",

keywords = "Case-Control Studies, Endocrine Disruptors, Europe, Female, Humans, Incidence, Lymphoma, Male, Occupational Diseases, Occupational Exposure, Risk Factors, Sex Factors, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't",

author = "L Costas and C Infante-Rivard and J-P Zock and {Van Tongeren}, M and P Boffetta and A Cusson and C Robles and D Casabonne and Y Benavente and N Becker and P Brennan and L Foretova and M Maynadi{\'e} and A Staines and A Nieters and P Cocco and {de Sanjos{\'e}}, S",

year = "2015",

month = mar,

day = "31",

doi = "10.1038/bjc.2015.83",

language = "English",

volume = "112",

pages = "1251--1256",

journal = "British Journal of Cancer",

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Costas, L, Infante-Rivard, C, Zock, J-P, Van Tongeren, M, Boffetta, P, Cusson, A, Robles, C, Casabonne, D, Benavente, Y, Becker, N, Brennan, P, Foretova, L, Maynadié, M, Staines, A, Nieters, A, Cocco, P & de Sanjosé, S 2015, 'Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study', British Journal of Cancer, vol. 112, no. 7, pp. 1251-1256. https://doi.org/10.1038/bjc.2015.83

TY - JOUR

T1 - Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study

AU - Costas, L

AU - Infante-Rivard, C

AU - Zock, J-P

AU - Van Tongeren, M

AU - Boffetta, P

AU - Cusson, A

AU - Robles, C

AU - Casabonne, D

AU - Benavente, Y

AU - Becker, N

AU - Brennan, P

AU - Foretova, L

AU - Maynadié, M

AU - Staines, A

AU - Nieters, A

AU - Cocco, P

AU - de Sanjosé, S

PY - 2015/3/31

Y1 - 2015/3/31

N2 - BACKGROUND: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma.METHODS: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study.RESULTS: Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend=0.02). Associations were observed among men, but not women.CONCLUSIONS: Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes.

AB - BACKGROUND: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma.METHODS: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study.RESULTS: Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend=0.02). Associations were observed among men, but not women.CONCLUSIONS: Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes.

KW - Case-Control Studies

KW - Endocrine Disruptors

KW - Europe

KW - Female

KW - Humans

KW - Incidence

KW - Lymphoma

KW - Male

KW - Occupational Diseases

KW - Occupational Exposure

KW - Risk Factors

KW - Sex Factors

KW - Journal Article

KW - Multicenter Study

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/bjc.2015.83

DO - 10.1038/bjc.2015.83

M3 - Article

C2 - 25742473

SN - 0007-0920

VL - 112

SP - 1251

EP - 1256

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 7

ER -

Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study

Abstract

Keywords

UN SDGs

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