Occupational solvent exposure and risk of glioma in the INTEROCC study

Geza Benke; Michelle C Turner; Sarah Fleming; Jordi Figuerola; Laurel Kincl; Lesley Richardson; Maria Blettner; Martine Hours; Daniel Krewski; David McLean; Marie-Elise Parent; Siegal Sadetzki; Klaus Schlaefer; Brigitte Schlehofer; Jack Siemiatycki; Martie van Tongeren; Elisabeth Cardis

doi:10.1038/bjc.2017.285

Occupational solvent exposure and risk of glioma in the INTEROCC study

Geza Benke, Michelle C Turner, Sarah Fleming, Jordi Figuerola, Laurel Kincl, Lesley Richardson, Maria Blettner, Martine Hours, Daniel Krewski, David McLean, Marie-Elise Parent, Siegal Sadetzki, Klaus Schlaefer, Brigitte Schlehofer, Jack Siemiatycki, Martie van Tongeren, Elisabeth Cardis

Division of Population Health, Health Services Research & Primary Care (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: The aetiology of glioma remains largely unknown. Occupational solvent exposure has been suggested as a putative cause of glioma, but past studies have been inconsistent. We examined the association between a range of solvents and glioma risk within the INTEROCC project, a study of brain tumours and occupational exposures based on data from seven national case-control studies conducted in the framework of the INTERPHONE study. We also investigated associations according to tumour grade.

METHODS: Data from the seven countries were standardised and then combined into one aggregate data set. Pooled odds ratios (ORs) were estimated for adjusted models that included sex, age, country-region of residence and level of educational attainment. Exposures to any solvent or 11 specific solvents or subgroups were assessed using a modified version of the FINJEM job exposure matrix (JEM) specifically developed for the study, called INTEROCC-JEM.

RESULTS: Analysis included 2000 glioma cases and 5565 controls. For glioma and ever/never exposure to any solvent, the OR was 0.91 (95% confidence interval: 0.74-1.11). All ORs were <1.0 for specific solvents/subgroups. There were no increases in risk according to high or low grade of tumour.

CONCLUSIONS: The results of this study show no consistent associations for any solvent exposures overall or by grade of tumour.British Journal of Cancer advance online publication 14 September 2017; doi:10.1038/bjc.2017.285 www.bjcancer.com.

Original language	English
Pages (from-to)	1246-1254
Number of pages	8
Journal	BJC
Volume	117
Early online date	14 Sept 2017
DOIs	https://doi.org/10.1038/bjc.2017.285
Publication status	Published - 10 Oct 2017

Keywords

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Benke, G., Turner, M. C., Fleming, S., Figuerola, J., Kincl, L., Richardson, L., Blettner, M., Hours, M., Krewski, D., McLean, D., Parent, M.-E., Sadetzki, S., Schlaefer, K., Schlehofer, B., Siemiatycki, J., van Tongeren, M., & Cardis, E. (2017). Occupational solvent exposure and risk of glioma in the INTEROCC study. BJC, 117, 1246-1254. https://doi.org/10.1038/bjc.2017.285

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abstract = "BACKGROUND: The aetiology of glioma remains largely unknown. Occupational solvent exposure has been suggested as a putative cause of glioma, but past studies have been inconsistent. We examined the association between a range of solvents and glioma risk within the INTEROCC project, a study of brain tumours and occupational exposures based on data from seven national case-control studies conducted in the framework of the INTERPHONE study. We also investigated associations according to tumour grade.METHODS: Data from the seven countries were standardised and then combined into one aggregate data set. Pooled odds ratios (ORs) were estimated for adjusted models that included sex, age, country-region of residence and level of educational attainment. Exposures to any solvent or 11 specific solvents or subgroups were assessed using a modified version of the FINJEM job exposure matrix (JEM) specifically developed for the study, called INTEROCC-JEM.RESULTS: Analysis included 2000 glioma cases and 5565 controls. For glioma and ever/never exposure to any solvent, the OR was 0.91 (95% confidence interval: 0.74-1.11). All ORs were <1.0 for specific solvents/subgroups. There were no increases in risk according to high or low grade of tumour.CONCLUSIONS: The results of this study show no consistent associations for any solvent exposures overall or by grade of tumour.British Journal of Cancer advance online publication 14 September 2017; doi:10.1038/bjc.2017.285 www.bjcancer.com.",

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author = "Geza Benke and Turner, {Michelle C} and Sarah Fleming and Jordi Figuerola and Laurel Kincl and Lesley Richardson and Maria Blettner and Martine Hours and Daniel Krewski and David McLean and Marie-Elise Parent and Siegal Sadetzki and Klaus Schlaefer and Brigitte Schlehofer and Jack Siemiatycki and {van Tongeren}, Martie and Elisabeth Cardis",

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AU - Benke, Geza

AU - Turner, Michelle C

AU - Fleming, Sarah

AU - Figuerola, Jordi

AU - Kincl, Laurel

AU - Richardson, Lesley

AU - Blettner, Maria

AU - Hours, Martine

AU - Krewski, Daniel

AU - McLean, David

AU - Parent, Marie-Elise

AU - Sadetzki, Siegal

AU - Schlaefer, Klaus

AU - Schlehofer, Brigitte

AU - Siemiatycki, Jack

AU - van Tongeren, Martie

AU - Cardis, Elisabeth

PY - 2017/10/10

Y1 - 2017/10/10

N2 - BACKGROUND: The aetiology of glioma remains largely unknown. Occupational solvent exposure has been suggested as a putative cause of glioma, but past studies have been inconsistent. We examined the association between a range of solvents and glioma risk within the INTEROCC project, a study of brain tumours and occupational exposures based on data from seven national case-control studies conducted in the framework of the INTERPHONE study. We also investigated associations according to tumour grade.METHODS: Data from the seven countries were standardised and then combined into one aggregate data set. Pooled odds ratios (ORs) were estimated for adjusted models that included sex, age, country-region of residence and level of educational attainment. Exposures to any solvent or 11 specific solvents or subgroups were assessed using a modified version of the FINJEM job exposure matrix (JEM) specifically developed for the study, called INTEROCC-JEM.RESULTS: Analysis included 2000 glioma cases and 5565 controls. For glioma and ever/never exposure to any solvent, the OR was 0.91 (95% confidence interval: 0.74-1.11). All ORs were <1.0 for specific solvents/subgroups. There were no increases in risk according to high or low grade of tumour.CONCLUSIONS: The results of this study show no consistent associations for any solvent exposures overall or by grade of tumour.British Journal of Cancer advance online publication 14 September 2017; doi:10.1038/bjc.2017.285 www.bjcancer.com.

AB - BACKGROUND: The aetiology of glioma remains largely unknown. Occupational solvent exposure has been suggested as a putative cause of glioma, but past studies have been inconsistent. We examined the association between a range of solvents and glioma risk within the INTEROCC project, a study of brain tumours and occupational exposures based on data from seven national case-control studies conducted in the framework of the INTERPHONE study. We also investigated associations according to tumour grade.METHODS: Data from the seven countries were standardised and then combined into one aggregate data set. Pooled odds ratios (ORs) were estimated for adjusted models that included sex, age, country-region of residence and level of educational attainment. Exposures to any solvent or 11 specific solvents or subgroups were assessed using a modified version of the FINJEM job exposure matrix (JEM) specifically developed for the study, called INTEROCC-JEM.RESULTS: Analysis included 2000 glioma cases and 5565 controls. For glioma and ever/never exposure to any solvent, the OR was 0.91 (95% confidence interval: 0.74-1.11). All ORs were <1.0 for specific solvents/subgroups. There were no increases in risk according to high or low grade of tumour.CONCLUSIONS: The results of this study show no consistent associations for any solvent exposures overall or by grade of tumour.British Journal of Cancer advance online publication 14 September 2017; doi:10.1038/bjc.2017.285 www.bjcancer.com.

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DO - 10.1038/bjc.2017.285

M3 - Article

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SN - 0007-0920

VL - 117

SP - 1246

EP - 1254

JO - BJC

JF - BJC

ER -

Occupational solvent exposure and risk of glioma in the INTEROCC study

Abstract

Keywords

UN SDGs

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