TY - JOUR
T1 - Occupational solvent exposure and risk of meningioma
T2 - results from the INTEROCC multicentre case-control study
AU - McLean, Dave
AU - Fleming, Sarah
AU - Turner, Michelle C
AU - Kincl, Laurel
AU - Richardson, Lesley
AU - Benke, Geza
AU - Schlehofer, Brigitte
AU - Schlaefer, Klaus
AU - Parent, Marie-Elise
AU - Hours, Martine
AU - Krewski, Daniel
AU - van Tongeren, Martie
AU - Sadetzki, Siegal
AU - Siemiatycki, Jack
AU - Cardis, Elisabeth
PY - 2014/4
Y1 - 2014/4
N2 - OBJECTIVE: To examine associations between occupational exposure to selected organic solvents and meningioma.METHODOLOGY: A multicentre case-control study conducted in seven countries, including 1906 cases and 5565 controls. Occupational exposure to selected classes of organic solvents (aliphatic and alicyclic hydrocarbons, aromatic hydrocarbons, chlorinated hydrocarbons and 'other' organic solvents) or seven specific solvents (benzene, toluene, trichloroethylene, perchloroethylene, 1,1,1-trichloroethylene, methylene chloride and gasoline) was assessed using lifetime occupational histories and a modified version of the FINJEM job-exposure matrix (INTEROCC-JEM). Study participants were classified as 'exposed' when they had worked in an occupation for at least 1 year, with a 5-year lag, in which the estimated prevalence of exposure was 25% or greater in the INTEROCC-JEM. Associations between meningioma and each of the solvent exposures were estimated using conditional logistic regression, adjusting for potential confounders.RESULTS: A total of 6.5% of study participants were ever exposed to 'any' solvent, with a somewhat greater proportion of controls (7%) ever exposed compared with cases (5%), but only one case was ever exposed to any chlorinated hydrocarbon (1,1,1-trichloroethane). No association was observed between any of the organic solvents and meningioma, in either men or women, and no dose-response relationships were observed in internal analyses using either exposure duration or cumulative exposure.DISCUSSION: We found no evidence that occupational exposure to these organic solvents is associated with meningioma.
AB - OBJECTIVE: To examine associations between occupational exposure to selected organic solvents and meningioma.METHODOLOGY: A multicentre case-control study conducted in seven countries, including 1906 cases and 5565 controls. Occupational exposure to selected classes of organic solvents (aliphatic and alicyclic hydrocarbons, aromatic hydrocarbons, chlorinated hydrocarbons and 'other' organic solvents) or seven specific solvents (benzene, toluene, trichloroethylene, perchloroethylene, 1,1,1-trichloroethylene, methylene chloride and gasoline) was assessed using lifetime occupational histories and a modified version of the FINJEM job-exposure matrix (INTEROCC-JEM). Study participants were classified as 'exposed' when they had worked in an occupation for at least 1 year, with a 5-year lag, in which the estimated prevalence of exposure was 25% or greater in the INTEROCC-JEM. Associations between meningioma and each of the solvent exposures were estimated using conditional logistic regression, adjusting for potential confounders.RESULTS: A total of 6.5% of study participants were ever exposed to 'any' solvent, with a somewhat greater proportion of controls (7%) ever exposed compared with cases (5%), but only one case was ever exposed to any chlorinated hydrocarbon (1,1,1-trichloroethane). No association was observed between any of the organic solvents and meningioma, in either men or women, and no dose-response relationships were observed in internal analyses using either exposure duration or cumulative exposure.DISCUSSION: We found no evidence that occupational exposure to these organic solvents is associated with meningioma.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Female
KW - Humans
KW - Logistic Models
KW - Male
KW - Meningeal Neoplasms
KW - Meningioma
KW - Middle Aged
KW - Occupational Diseases
KW - Occupational Exposure
KW - Solvents
KW - Young Adult
KW - Journal Article
KW - Multicenter Study
KW - Research Support, N.I.H., Extramural
KW - Research Support, Non-U.S. Gov't
U2 - 10.1136/oemed-2013-101780
DO - 10.1136/oemed-2013-101780
M3 - Article
C2 - 24474387
SN - 1351-0711
VL - 71
SP - 253
EP - 258
JO - Occupational and Environmental Medicine
JF - Occupational and Environmental Medicine
IS - 4
ER -