@inbook{7eef2f107476438eb44077ae42282e6b,
title = "Oligodendroglia in Neuromyelitis Optica Spectrum Disorder",
abstract = "Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory autoimmune disease of the central nervous system, in which aquaporin-4 immunoglobulin G (AQP4-IgG) targets the water channel aquaporin-4 (AQP4) localized at astrocytic endfeet, thus triggering inflammatory lesions and tissue damage. The pathological characteristics of NMOSD are early loss of oligodendrocytes, extensive demyelination, and axonal injury. The pathogenesis of oligodendrocyte damage in NMOSD includes complement-dependent bystander effect, antibody-dependent cell-mediated cytotoxicity bystander effect, glutamate toxicity, connexin dysregulation, and blood-brain barrier disruption. Remyelination levels in acute NMOSD lesions are low.",
keywords = "neuromyelitis optica spectrum disorder, Oligodendroglia, Aquaporin-4 immunoglobulin G, astrocytes",
author = "Ai Guo and Yuzhen Wei and Alexei Verkhratsky and Fu-Dong Shi",
note = "{\textcopyright} 2025. The Author(s), under exclusive license to Springer Nature Switzerland AG.",
year = "2025",
month = jun,
day = "12",
doi = "10.1007/978-3-031-87919-7\_16",
language = "English",
isbn = "9783031879180",
series = "Advances in Neurobiology ",
publisher = "Springer Cham",
pages = "457--472",
editor = "Chenju Yi and Arthur Butt and Alexei Verkhratsky and Jianqin Niu",
booktitle = "Physiology and Pathophysiology of Oligodendroglia",
address = "Switzerland",
}