One-dimensional DOSY

A new NMR experiment for correlating diffusion coefficients and chemical shifts is presented. This experiment provides the same information as the conventional DOSY experiment, but only requires a single dimension because a nonuniform magnetic field gradient is used to encode the diffusion information into the lineshapes of the peaks in the chemical shift dimension. By fitting the resulting line-shapes, the diffusion coefficient for each peak in the spectrum can be extracted. Using this experiment, a qualitative DOSY spectrum can be generated using the results from a single one-dimensional experiment. Quantitative results can be determined with the use of reference experiments. © 2001 Academic Press.