One-pot multistep synthetic strategies for the production of fenpropimorph using an ionic liquid solvent

Stewart A. Forsyth; H. Q Nimal Gunaratne; Christopher Hardacre; Angela McKeown; David W. Rooney

doi:10.1021/op050172m

One-pot multistep synthetic strategies for the production of fenpropimorph using an ionic liquid solvent

Stewart A. Forsyth, H. Q Nimal Gunaratne, Christopher Hardacre, Angela McKeown, David W. Rooney

Queen's University Belfast

Research output: Contribution to journal › Article › peer-review

Abstract

The one-pot synthesis of the fungicide fenpropimorph has been achieved using two different synthetic strategies in an ionic liquid. The first pathway consists of a Heck coupling followed by reductive animation; the second pathway consists of an aldol condensation followed by hydrogenation/reductive animation. Homogeneous and heterogeneous palladium catalysts have been utilised in the ionic liquid to provide a catalyst/solvent system that is suitable for recycling and process optimisation.

Original language	English
Pages (from-to)	94-102
Number of pages	9
Journal	Organic Process Research and Development
Volume	10
Issue number	1
DOIs	https://doi.org/10.1021/op050172m
Publication status	Published - Jan 2006

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10.1021/op050172m

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abstract = "The one-pot synthesis of the fungicide fenpropimorph has been achieved using two different synthetic strategies in an ionic liquid. The first pathway consists of a Heck coupling followed by reductive animation; the second pathway consists of an aldol condensation followed by hydrogenation/reductive animation. Homogeneous and heterogeneous palladium catalysts have been utilised in the ionic liquid to provide a catalyst/solvent system that is suitable for recycling and process optimisation.",

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One-pot multistep synthetic strategies for the production of fenpropimorph using an ionic liquid solvent

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