TY - JOUR
T1 - OpenMandible
T2 - An open-source framework for highly realistic numerical modelling of lower mandible physiology
AU - Vukicevic, Arso M.
AU - Zelic, Ksenija
AU - Milasinovic, Danko
AU - Sarrami-Foroushani, Ali
AU - Jovicic, Gordana
AU - Milovanovic, Petar
AU - Djuric, Marija
AU - Filipovic, Nenad
AU - Frangi, Alejandro F.
N1 - Funding Information:
This study was funded by grants from Serbian Ministry of Education, Science, and Technological Development [451-03-68/2020-14/200107 (Faculty of Engineering, University of Kragujevac)], and [45005 (School of Medicine, University of Belgrade)]. P.M. was also partially funded by the Science Fund of Republic of Serbia, PROMIS, #6064549. A.F.F. acknowledges support from the Royal Academy of Engineering under the RAEng Chairin Emerging Technologies (CiET1919/19) scheme. The Titan V GPU used for this research was donated by the NVIDIA Corporation to A.M.V.
Funding Information:
This study was funded by grants from Serbian Ministry of Education, Science, and Technological Development [ 451-03-68/2020-14/200107 (Faculty of Engineering, University of Kragujevac)], and [ 45005 (School of Medicine, University of Belgrade)]. P.M. was also partially funded by the Science Fund of Republic of Serbia , PROMIS, #6064549. A.F.F. acknowledges support from the Royal Academy of Engineering under the RAEng Chairin Emerging Technologies (CiET1919/19) scheme. The Titan V GPU used for this research was donated by the NVIDIA Corporation to A.M.V.
Publisher Copyright:
© 2021 The Academy of Dental Materials
PY - 2021/4/1
Y1 - 2021/4/1
N2 - Objective: Computer modeling of lower mandible physiology remains challenging because prescribing realistic material characteristics and boundary conditions from medical scans requires advanced equipment and skill sets. The objective of this study is to provide a framework that could reduce simplifications made and inconsistency (in terms of geometry, materials, and boundary conditions) among further studies on the topic. Methods: The OpenMandible framework offers: 1) the first publicly available multiscale model of the mandible developed by combining cone beam computerized tomography (CBCT) and μCT imaging modalities, and 2) a C++ software tool for the generation of simulation-ready models (tet4 and hex8 elements). In addition to the application of conventional (Neumann and Dirichlet) boundary conditions, OpenMandible introduces a novel geodesic wave propagation - based approach for incorporating orthotropic micromechanical characteristics of cortical bone, and a unique algorithm for modeling muscles as uniformly directed vectors. The base intact model includes the mandible (spongy and compact bone), 14 teeth (comprising dentin, enamel, periodontal ligament, and pulp), simplified temporomandibular joints, and masticatory muscles (masseter, temporalis, medial, and lateral pterygoid). Results: The complete source code, executables, showcases, and sample data are freely available on the public repository: https://github.com/ArsoVukicevic/OpenMandible. It has been demonstrated that by slightly editing the baseline model, one can study different “virtual” treatments or diseases, including tooth restoration, placement of implants, mandible bone degradation, and others. Significance: OpenMandible eases the community to undertake a broad range of studies on the topic, while increasing their consistency and reproducibility. At the same time, the needs for dedicated equipment and skills for developing realistic simulation models are significantly reduced.
AB - Objective: Computer modeling of lower mandible physiology remains challenging because prescribing realistic material characteristics and boundary conditions from medical scans requires advanced equipment and skill sets. The objective of this study is to provide a framework that could reduce simplifications made and inconsistency (in terms of geometry, materials, and boundary conditions) among further studies on the topic. Methods: The OpenMandible framework offers: 1) the first publicly available multiscale model of the mandible developed by combining cone beam computerized tomography (CBCT) and μCT imaging modalities, and 2) a C++ software tool for the generation of simulation-ready models (tet4 and hex8 elements). In addition to the application of conventional (Neumann and Dirichlet) boundary conditions, OpenMandible introduces a novel geodesic wave propagation - based approach for incorporating orthotropic micromechanical characteristics of cortical bone, and a unique algorithm for modeling muscles as uniformly directed vectors. The base intact model includes the mandible (spongy and compact bone), 14 teeth (comprising dentin, enamel, periodontal ligament, and pulp), simplified temporomandibular joints, and masticatory muscles (masseter, temporalis, medial, and lateral pterygoid). Results: The complete source code, executables, showcases, and sample data are freely available on the public repository: https://github.com/ArsoVukicevic/OpenMandible. It has been demonstrated that by slightly editing the baseline model, one can study different “virtual” treatments or diseases, including tooth restoration, placement of implants, mandible bone degradation, and others. Significance: OpenMandible eases the community to undertake a broad range of studies on the topic, while increasing their consistency and reproducibility. At the same time, the needs for dedicated equipment and skills for developing realistic simulation models are significantly reduced.
KW - Dentistry
KW - Mandible
KW - Open source
KW - OpenMandible
KW - Simulation
UR - https://www.scopus.com/pages/publications/85101371626
U2 - 10.1016/j.dental.2021.01.009
DO - 10.1016/j.dental.2021.01.009
M3 - Article
C2 - 33602549
AN - SCOPUS:85101371626
SN - 0109-5641
VL - 37
SP - 612
EP - 624
JO - Dental Materials
JF - Dental Materials
IS - 4
ER -