Opioidergic interactions between striatal projection neurons

Craig P. Blomeley, Enrico Bracci

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Medium spiny striatal projection neurons (MSNs) release opioid neuropeptides, but the role of these neurotransmitters is still poorly understood. While presynaptic inhibition of corticostriatal axons by opioid receptors has been demonstrated using exogenous ligands, the action of synaptically released opioids in the striatum has not been investigated. We performed single and paired whole-cell recordings from rat MSNs while corticostriatal fibers were electrically activated. In single recording experiments, we also activated antidromically the axons of a population of MSNs. Corticostriatal fibers were stimulated once every 10 s and every other stimulation was preceded by 5 antidromic spikes (at 100 Hz). This burst of antidromic spikes produced robust inhibition of evoked corticostriatal responses. This inhibition was not affected by the δ-opioid receptor antagonist SDM25N, but was completely abolished by the μ-opioid receptor antagonist CTOP. Inhibitory effects were maximal (on average 29.6±11.4%) when the burst preceded the corticostriatal stimulation by 500ms and became undetectable for intervals>2 s. Paired recordings from MSNs located
    Original languageEnglish
    Pages (from-to)13346-13356
    Number of pages10
    JournalJournal of Neuroscience
    Volume31
    Issue number38
    DOIs
    Publication statusPublished - 21 Sept 2011

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