Optic neuritis: Variations in temporal modulation sensitivity with retinal eccentricity

Graham K. Edgar, David H. Foster, William P. Honan, James R. Heron, Rosemary S. Snelgar

    Research output: Contribution to journalArticlepeer-review


    Temporal modulation sensitivity functions were measured centrally and at eccentricities of 2.5°, 5° and 10° in the temporal visual field of 12 patients with recovered optic neuritis and in a group of matched normal controls. A circular, spatially uniform stimulus of 1° angular subtense was presented with sinusoidal modulation at 5, 8, 14 and 23 Hz. The general pattern of results in patients was a loss of sensitivity relative to normal controls at all temporal frequencies at 0° and 2.5° eccentricity, with rather greater losses occurring at the medium-to-lower temporal frequencies. At 5° eccentricity, the losses were confined to medium temporal frequencies only, and at 10° eccentricity there was no significant loss at any temporal frequency. These findings may be explained by a greater vulnerability of optic nerve fibres of small diameter to the effects of demyelinating disease.
    Original languageEnglish
    Pages (from-to)487-496
    Number of pages9
    Issue number2
    Publication statusPublished - Apr 1990


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