@article{d76edd5b845940188b0c33d1d6204e8a,
title = "Optimisation of aqueous solubility in a series of G protein coupled receptor 119 (GPR119) agonists",
abstract = "Improving aqueous solubility is a challenge frequently faced within drug discovery programs. Herein we describe increases in solubility in two sub-series of GPR119 agonists through reduction of lipophilicity together with hydrogen bond acceptor modulation. Small molecule X-ray crystallography was utilised to investigate effects on solid state interactions.",
author = "Scott, {James S.} and Birch, {Alan M.} and Brocklehurst, {Katy J.} and Brown, {Hayley S.} and Kristin Goldberg and Groombridge, {Sam D.} and Hudson, {Julian A.} and Leach, {Andrew G.} and MacFaul, {Philip A.} and Darren McKerrecher and Ruth Poultney and Paul Schofield and Svensson, {Per H.}",
year = "2013",
month = jan,
doi = "10.1039/c2md20130e",
language = "English",
volume = "4",
pages = "95--100",
journal = "MedChemComm",
issn = "2040-2503",
publisher = "Royal Society of Chemistry",
number = "1",
}