Oral contraceptive (OCP) use increases proliferation and decreases oestrogen receptor content of epithelial cells in the normal human breast

G. Williams; E. Anderson; A. Howell; R. Watson; J. Coyne; S. A. Roberts; C. S. Potten

Oral contraceptive (OCP) use increases proliferation and decreases oestrogen receptor content of epithelial cells in the normal human breast

G. Williams, E. Anderson, A. Howell, R. Watson, J. Coyne, S. A. Roberts, C. S. Potten

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of ingestion of oral contraceptives (OCP) on cell proliferation and oestrogen (ER) and progesterone receptor (PR) expression of the epithelial cells of the normal human breast was compared with findings in controls not taking OCPs. Histologically normal breast tissue was removed during operation for fibroadenoma or reduction mammoplasty in 216 women whose mean age was 28.1 ± 8.5 years (±SD range 14-53 years). During natural cycles the mean proportion of cells expressing ER was 3.94 ± 3.71 (% mean ±SD, range 0-20.8, n = 51), while of those expressing PR it was 12.1 ± 7.1% (range 3.0-36.1, n = 47). There was a significant decline in ER during the menstrual cycle [p =

Original language	English
Pages (from-to)	206-210
Number of pages	4
Journal	International Journal of Cancer
Volume	48
Issue number	2
Publication status	Published - 1991

Keywords

Adolescence
Adult
AGE
Aging
Breast
breast cancer
BREAST-CANCER
CANCER
Cell Division
CELLS
Contraceptives,Oral
cytology
drug effects
Epithelium
EXPRESSION
Female
Human
human breast
Immunoenzyme Techniques
Menstrual Cycle
MENSTRUAL-CYCLE
METABOLISM
Middle Age
NUMBER
Parity
pathology
pharmacology
physiology
PROLIFERATION
Receptors,Estrogen
Receptors,Progesterone
Reproducibility of Results
Support,Non-U.S.Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Oral contraceptive (OCP) use increases proliferation and decreases oestrogen receptor content of epithelial cells in the normal human breast",

abstract = "The effect of ingestion of oral contraceptives (OCP) on cell proliferation and oestrogen (ER) and progesterone receptor (PR) expression of the epithelial cells of the normal human breast was compared with findings in controls not taking OCPs. Histologically normal breast tissue was removed during operation for fibroadenoma or reduction mammoplasty in 216 women whose mean age was 28.1 ± 8.5 years (±SD range 14-53 years). During natural cycles the mean proportion of cells expressing ER was 3.94 ± 3.71 (% mean ±SD, range 0-20.8, n = 51), while of those expressing PR it was 12.1 ± 7.1% (range 3.0-36.1, n = 47). There was a significant decline in ER during the menstrual cycle [p =",

keywords = "Adolescence, Adult, AGE, Aging, Breast, breast cancer, BREAST-CANCER, CANCER, Cell Division, CELLS, Contraceptives,Oral, cytology, drug effects, Epithelium, EXPRESSION, Female, Human, human breast, Immunoenzyme Techniques, Menstrual Cycle, MENSTRUAL-CYCLE, METABOLISM, Middle Age, NUMBER, Parity, pathology, pharmacology, physiology, PROLIFERATION, Receptors,Estrogen, Receptors,Progesterone, Reproducibility of Results, Support,Non-U.S.Gov't",

author = "G. Williams and E. Anderson and A. Howell and R. Watson and J. Coyne and Roberts, {S. A.} and Potten, {C. S.}",

note = "UI - 91209994LA - engRN - 0 (Contraceptives, Oral)RN - 0 (Receptors, Estrogen)RN - 0 (Receptors, Progesterone)PT - Journal ArticleDA - 19910528IS - 0020-7136SB - IMCY - UNITED STATESJC - GQU",

year = "1991",

language = "English",

volume = "48",

pages = "206--210",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "John Wiley & Sons Ltd",

number = "2",

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TY - JOUR

T1 - Oral contraceptive (OCP) use increases proliferation and decreases oestrogen receptor content of epithelial cells in the normal human breast

AU - Williams, G.

AU - Anderson, E.

AU - Howell, A.

AU - Watson, R.

AU - Coyne, J.

AU - Roberts, S. A.

AU - Potten, C. S.

N1 - UI - 91209994LA - engRN - 0 (Contraceptives, Oral)RN - 0 (Receptors, Estrogen)RN - 0 (Receptors, Progesterone)PT - Journal ArticleDA - 19910528IS - 0020-7136SB - IMCY - UNITED STATESJC - GQU

PY - 1991

Y1 - 1991

N2 - The effect of ingestion of oral contraceptives (OCP) on cell proliferation and oestrogen (ER) and progesterone receptor (PR) expression of the epithelial cells of the normal human breast was compared with findings in controls not taking OCPs. Histologically normal breast tissue was removed during operation for fibroadenoma or reduction mammoplasty in 216 women whose mean age was 28.1 ± 8.5 years (±SD range 14-53 years). During natural cycles the mean proportion of cells expressing ER was 3.94 ± 3.71 (% mean ±SD, range 0-20.8, n = 51), while of those expressing PR it was 12.1 ± 7.1% (range 3.0-36.1, n = 47). There was a significant decline in ER during the menstrual cycle [p =

AB - The effect of ingestion of oral contraceptives (OCP) on cell proliferation and oestrogen (ER) and progesterone receptor (PR) expression of the epithelial cells of the normal human breast was compared with findings in controls not taking OCPs. Histologically normal breast tissue was removed during operation for fibroadenoma or reduction mammoplasty in 216 women whose mean age was 28.1 ± 8.5 years (±SD range 14-53 years). During natural cycles the mean proportion of cells expressing ER was 3.94 ± 3.71 (% mean ±SD, range 0-20.8, n = 51), while of those expressing PR it was 12.1 ± 7.1% (range 3.0-36.1, n = 47). There was a significant decline in ER during the menstrual cycle [p =

KW - Adolescence

KW - Adult

KW - AGE

KW - Aging

KW - Breast

KW - breast cancer

KW - BREAST-CANCER

KW - CANCER

KW - Cell Division

KW - CELLS

KW - Contraceptives,Oral

KW - cytology

KW - drug effects

KW - Epithelium

KW - EXPRESSION

KW - Female

KW - Human

KW - human breast

KW - Immunoenzyme Techniques

KW - Menstrual Cycle

KW - MENSTRUAL-CYCLE

KW - METABOLISM

KW - Middle Age

KW - NUMBER

KW - Parity

KW - pathology

KW - pharmacology

KW - physiology

KW - PROLIFERATION

KW - Receptors,Estrogen

KW - Receptors,Progesterone

KW - Reproducibility of Results

KW - Support,Non-U.S.Gov't

M3 - Article

SN - 0020-7136

VL - 48

SP - 206

EP - 210

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 2

ER -

Oral contraceptive (OCP) use increases proliferation and decreases oestrogen receptor content of epithelial cells in the normal human breast

Abstract

Keywords

UN SDGs

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