Oral mucosal bioadhesive tablets of pectin and HPMC: In vitro and in vivo evaluation

S. Miyazaki, N. Kawasaki, T. Nakamura, M. Iwatsu, T. Hayashi, W. M. Hou, D. Attwood

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The potential of tablets containing 1:4, 1:1 and 4:1 weight ratios of pectin and hydroxypropyl methylcellulose (HPMC) for the sustained release of diltiazem by sublingual administration has been investigated. Measurements of maximum adhesive force to rat peritoneal membrane indicated a satisfactory bioadhesive strength. An in vitro sustained release of diltiazem over 5 h was achieved with bilayer tablets composed of a drug-free ethylcellulose layer in addition to the pectin/HPMC layer containing drug. Plasma concentration-time curves obtained following sublingual administration to rabbits of single and bilayer tablets with 1:1 weight ratios of pectin and HPMC showed evidence of sustained release of diltiazem. Bioavailability of diltiazem was 2.5 times that achieved by oral administration for single layer tablets and 1.8 times for the bilayered tablets. (C) 2000 Elsevier Science B.V.
    Original languageEnglish
    Pages (from-to)127-132
    Number of pages5
    JournalInternational Journal of Pharmaceutics
    Volume204
    Issue number1-2
    DOIs
    Publication statusPublished - 20 Jun 2000

    Keywords

    • Diltiazem
    • Pectin/HPMC tablets
    • Sublingual drug delivery
    • Sustained release

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