Oral sustained delivery of paracetamol from in situ gelling xyloglucan formulations

Shozo Miyazaki, Kumiko Endo, Naoko Kawasaki, Wataru Kubo, Hideki Watanabe, David Attwood

    Research output: Contribution to journalArticlepeer-review


    The purpose of this study was to evaluate the potential of a xyloglucan formulation with in situ gelling properties for the oral sustained delivery of paracetamol. Gelation of dilute aqueous solutions of the polysaccharide xyloglucan occurred in rabbit and rat stomachs as the orally administered chilled solutions attained body temperature. In vitro studies demonstrated diffusion-controlled release of paracetamol from the gels over a period of 6 hr. The bioavailabilities of paracetamol from the xyloglucan gels formed in situ in the stomachs of rabbits after oral administration of the liquid formulations were similar to that of a commercially available suspension containing an identical dose of paracetamol.
    Original languageEnglish
    Pages (from-to)113-119
    Number of pages6
    JournalDrug Development and Industrial Pharmacy
    Issue number2
    Publication statusPublished - 2003


    • In situ gelation
    • Oral drug delivery
    • Paracetamol
    • Sustained release
    • Xyloglucan gels


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