Organizing the genome with H2A histone variants

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Chromatin acts as an organizer and indexer of genomic DNA and is a highly dynamic and regulated structure with properties directly related to its constituent parts. Histone variants are abundant components of chromatin that replace canonical histones in a subset of nucleosomes, thereby altering nucleosomal characteristics. The present review focuses on the H2A variant histones, summarizing current knowledge of how H2A variants can introduce chemical and functional heterogeneity into chromatin, the positions that nucleosomes containing H2A variants occupy in eukaryotic genomes, and the regulation of these localization patterns. © The Authors Journal compilation © 2013 Biochemical Society.
    Original languageEnglish
    Pages (from-to)567-579
    Number of pages12
    JournalBiochemical Journal
    Volume449
    Issue number3
    DOIs
    Publication statusPublished - 1 Feb 2013

    Keywords

    • Chromatin
    • H2A.B
    • H2A.X
    • H2A.Z
    • Histone variant
    • mH2A

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