TY - JOUR
T1 - Organoids in the Clinic
T2 - A Systematic Review of Outcomes
AU - Hofmann, Bjørn
AU - Zinöcker, Severin
AU - Holm, Søren
AU - Lewis, Jonathan
AU - Kavouras, Panagiotis
N1 - © 2022 The Author(s). Published by S. Karger AG, Basel.
PY - 2022/9/28
Y1 - 2022/9/28
N2 - Research on organoids has undergone significant advances during the last decade. However, outcomes from the use of organoids in clinical trials have not yet been documented. Therefore, there is an urgent need to assess the reporting of clinically relevant outcomes from organoid research in the scientific literature. This article presents a systematic review and appraisal of the published literature in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, together with a synopsis of recent relevant reviews. Surprisingly, no randomized controlled trials have reported clinical outcomes with any types of organoids. We found very few ongoing and registered studies that may provide clinically relevant results within this decade. Our screening and interpretation of the literature, including review articles, indicate a focus on technical and preclinical aspects of organoid research. This is the first systematic review of clinical trials involving organoids. Few clinical studies are planned or already underway, and, so far, no high-quality evidence relating to the clinical outcomes of organoid research has been published. The many promises of organoid research still need to be translated from bench to bed.
AB - Research on organoids has undergone significant advances during the last decade. However, outcomes from the use of organoids in clinical trials have not yet been documented. Therefore, there is an urgent need to assess the reporting of clinically relevant outcomes from organoid research in the scientific literature. This article presents a systematic review and appraisal of the published literature in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, together with a synopsis of recent relevant reviews. Surprisingly, no randomized controlled trials have reported clinical outcomes with any types of organoids. We found very few ongoing and registered studies that may provide clinically relevant results within this decade. Our screening and interpretation of the literature, including review articles, indicate a focus on technical and preclinical aspects of organoid research. This is the first systematic review of clinical trials involving organoids. Few clinical studies are planned or already underway, and, so far, no high-quality evidence relating to the clinical outcomes of organoid research has been published. The many promises of organoid research still need to be translated from bench to bed.
KW - Evidence
KW - Organoids
KW - Outcomes
KW - Systematic review
UR - http://www.scopus.com/inward/record.url?scp=85160112484&partnerID=8YFLogxK
UR - https://doi.org/10.1159/000527237
U2 - 10.1159/000527237
DO - 10.1159/000527237
M3 - Article
C2 - 36170843
SN - 1422-6405
VL - 212
SP - 499
EP - 511
JO - Cells Tissues Organs
JF - Cells Tissues Organs
IS - 6
ER -