Orlistat-induced oxalate nephropathy: an under-recognised cause of chronic kidney disease

Laurence Solomon; Andrew Nixon; Leanne Ogden; Beena Nair

doi:10.1136/bcr-2016-218623

Orlistat-induced oxalate nephropathy: an under-recognised cause of chronic kidney disease

Laurence Solomon, Andrew Nixon, Leanne Ogden, Beena Nair

Division of Cardiovascular Sciences

Lancashire Teaching Hospitals NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

Abstract

Two patients developed kidney failure due to oxalate deposition in the kidney while taking orlistat. Cessation of orlistat was followed by partial recovery of kidney function. The mechanism by which orlistat causes hyperoxaluria and the management of orlistat-induced oxalate nephropathy is reviewed. We suggest that all patients taking orlistat are at risk of this condition, which may develop insidiously and is easily overlooked. Monitoring of kidney function of patients taking orlistat is warranted.

Original language	English
Journal	BMJ Case Reports
DOIs	https://doi.org/10.1136/bcr-2016-218623
Publication status	Published - 12 Nov 2017

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10.1136/bcr-2016-218623

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abstract = "Two patients developed kidney failure due to oxalate deposition in the kidney while taking orlistat. Cessation of orlistat was followed by partial recovery of kidney function. The mechanism by which orlistat causes hyperoxaluria and the management of orlistat-induced oxalate nephropathy is reviewed. We suggest that all patients taking orlistat are at risk of this condition, which may develop insidiously and is easily overlooked. Monitoring of kidney function of patients taking orlistat is warranted.",

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AB - Two patients developed kidney failure due to oxalate deposition in the kidney while taking orlistat. Cessation of orlistat was followed by partial recovery of kidney function. The mechanism by which orlistat causes hyperoxaluria and the management of orlistat-induced oxalate nephropathy is reviewed. We suggest that all patients taking orlistat are at risk of this condition, which may develop insidiously and is easily overlooked. Monitoring of kidney function of patients taking orlistat is warranted.

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Orlistat-induced oxalate nephropathy: an under-recognised cause of chronic kidney disease

Abstract

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