Oscillatory control of signalling molecules

Pawel Paszek, Dean A. Jackson, Michael R H White

    Research output: Contribution to journalArticlepeer-review


    The emergence of biological function from the dynamic control of cellular signalling molecules is a fundamental process in biology. Key questions include: How do cells decipher noisy environmental cues, encode these signals to control fate decisions and propagate information through tissues? Recent advances in systems biology, and molecular and cellular biology, exemplified by analyses of signalling via the transcription factor Nuclear Factor kappaB (NF-κB), reveal a critical role of oscillatory control in the regulation of these biological functions. The emerging view is that the oscillatory dynamics of signalling molecules and the epigenetically regulated specificity for target genes contribute to robust regulation of biological function at different levels of cellular organisation through frequency-dependent information encoding. © 2010 Elsevier Ltd.
    Original languageEnglish
    Pages (from-to)670-676
    Number of pages6
    JournalCurrent Opinion in Genetics and Development
    Issue number6
    Publication statusPublished - Dec 2010


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