Osteoblast nodule formation and mineralization on foamed 58s bioactive glass.

In this study the authors analyzed human osteoblast responses to a porous bioactive glass scaffold. Attachment, spreading and formation of mineralized nodules in response to culture on the bioactive glass were analyzed. Dissoln. products are a key feature of bioactive glasses and these were measured by inductively coupled plasma optical emission spectroscopy to det. effects of both the glass surface and ion release. Osteoblasts attached and proliferated on the foams as demonstrated by SEM. Nodule formation was also obsd. in the pores of the glass and also in conditioned medium contg. dissoln. products at certain concns. and these nodules were shown to be mineralized by alizarin red staining. [on SciFinder (R)]