Osteoblast Responses to Sintered and Tapecast Bioactive Glass

The manufacture of tape cast bioactive glasses allows the build up of layers and therefore the production of complex shapes. This therefore has applications to tissue repair where specific shapes are required such as repair of craniofacial defects. Tape cast discs sintered at temperatures from 800°C to 1000°C for 3 or 6 hours were used to culture primary human osteoblasts. Hydroxyapatite formation, cell attachment, cell death, and nodule formation, were studied. It was found that cell death and nodule formation were dependent on Si release concentrations and the development of the HA layer.