Osteoblast responses to tape-cast and sintered bioactive glass ceramics

J. E. Gough, D. C. Clupper, L. L. Hench

    Research output: Contribution to journalArticlepeer-review


    The advantage of tape-cast bioactive glasses lies in the manufacturing procedure, which allows the build-up of layers and, therefore, the production of complex shapes. This, therefore, has applications to tissue engineering, where specific shapes are required such as repair of craniofacial defects. The bioactivity of tape-cast discs sintered at temperatures ranging from 800°C to 1000°C and for 3 or 6 h was analyzed by FTIR. Tape-cast discs were used to culture primary human osteoblasts, and cell attachment, cell death, collagen production, nodule formation, and mineralization were studied. These responses were dependent upon Si and Na release profiles of the tape-cast discs, and development of the hydroxyapatite layer. © 2004 Wiley Periodicals, Inc.
    Original languageEnglish
    Pages (from-to)621-628
    Number of pages7
    JournalJournal of Biomedical Materials Research - Part A
    Issue number4
    Publication statusPublished - 15 Jun 2004


    • Bioactive
    • Primary human osteoblasts
    • Tape cast
    • Tissue engineering


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