Osteoblasts and their applications in bone tissue engineering

Asha Rupani, Richard Balint, Sarah H. Cartmell

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Abstract: Tissue engineering is an emerging therapy that offers a new solution to patients suffering from bone loss. It utilizes cells derived from such sources as a patient's own bone or bone marrow, which are laboratory-isolated, grown (so they multiply in number), and placed onto a degradable material, or scaffold, that has mechanical/chemical properties appropriate to the bone section that it is replacing. The cells plus the scaffold are then grown in a container, or bioreactor, which is necessary as it provides the correct environment required for the cells to proliferate, differentiate, and to produce extracellular matrix. The following review focuses on the use of osteoblasts for bone tissue engineering. © 2012 Rupani et al, publisher and licensee Dove Medical Press Ltd.
    Original languageEnglish
    Pages (from-to)49-61
    Number of pages12
    JournalCell Health and Cytoskeleton
    Volume4
    DOIs
    Publication statusPublished - 2012

    Keywords

    • Bone
    • Orthopaedic
    • Osteoblast
    • Regenerative medicine
    • Tissue engineering

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