Ostwald's rule and enantiotropy: polymorph appearance in the crystallisation of p-aminobenzoic acid

James F. B. Black; Roger Davey; Richard Gowers; Alvin Yeoh

doi:10.1039/C5CE00353A

Ostwald's rule and enantiotropy: polymorph appearance in the crystallisation of p-aminobenzoic acid

James F. B. Black, Roger Davey, Richard Gowers, Alvin Yeoh

Research output: Contribution to journal › Article › peer-review

Abstract

The development of rational crystallisation strategies in polymorphic systems requires the experimental manipulation of both kinetics and thermodynamics. We show for the first time the results of the interplay between these competing driving forces in an enantiotropic system, p-aminobenzoic acid. The outcomes are unexpected with temperature having no impact.

Original language	English
Pages (from-to)	5139-5142
Number of pages	3
Journal	CrystEngComm
Volume	17
Issue number	28
Early online date	27 Mar 2015
DOIs	https://doi.org/10.1039/C5CE00353A
Publication status	Published - 28 Jul 2015

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title = "Ostwald's rule and enantiotropy: polymorph appearance in the crystallisation of p-aminobenzoic acid",

abstract = "The development of rational crystallisation strategies in polymorphic systems requires the experimental manipulation of both kinetics and thermodynamics. We show for the first time the results of the interplay between these competing driving forces in an enantiotropic system, p-aminobenzoic acid. The outcomes are unexpected with temperature having no impact.",

author = "Black, {James F. B.} and Roger Davey and Richard Gowers and Alvin Yeoh",

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AU - Black, James F. B.

AU - Davey, Roger

AU - Gowers, Richard

AU - Yeoh, Alvin

N1 - This work was supported by IFPRI (AY), GSK (JB) and EPSRC (RJD).

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N2 - The development of rational crystallisation strategies in polymorphic systems requires the experimental manipulation of both kinetics and thermodynamics. We show for the first time the results of the interplay between these competing driving forces in an enantiotropic system, p-aminobenzoic acid. The outcomes are unexpected with temperature having no impact.

AB - The development of rational crystallisation strategies in polymorphic systems requires the experimental manipulation of both kinetics and thermodynamics. We show for the first time the results of the interplay between these competing driving forces in an enantiotropic system, p-aminobenzoic acid. The outcomes are unexpected with temperature having no impact.

U2 - 10.1039/C5CE00353A

DO - 10.1039/C5CE00353A

M3 - Article

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VL - 17

SP - 5139

EP - 5142

JO - CrystEngComm

JF - CrystEngComm

IS - 28

ER -

Ostwald's rule and enantiotropy: polymorph appearance in the crystallisation of p-aminobenzoic acid

Abstract

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