Otorhinolaryngological manifestations of the mucopolysaccharidoses

M. A. Simmons, I. A. Bruce, S. Penney, E. Wraith, M. P. Rothera

    Research output: Contribution to journalArticlepeer-review


    The mucopolysaccharidoses (MPS) are a family of related inherited metabolic disorders where, due to specific lysosomal enzyme deficiencies, partially degraded glycosaminoglycans (GAGs) accumulate in the body's cells. Due to the ubiquitous nature of GAGs in the body this deposition can occur in many tissue types and may interfere with cellular function. Although these conditions are rare, there is a propensity for the disease process to cause problems with the function of the ears, noses and throats of affected patients. In this review, we present an overview of the clinical manifestations of MPS in general and highlight the problems specifically presenting in the field of otorhinolaryngology. © 2005 Published by Elsevier Ireland Ltd.
    Original languageEnglish
    Pages (from-to)589-595
    Number of pages6
    JournalInternational journal of pediatric otorhinolaryngology
    Issue number5
    Publication statusPublished - May 2005


    • Mucopolysaccharidoses
    • Otolaryngology


    Dive into the research topics of 'Otorhinolaryngological manifestations of the mucopolysaccharidoses'. Together they form a unique fingerprint.

    Cite this