Otsutstvie nizkoporogovykh kal'tsievykh kanalov b membrane kul'tiviruemykh kletok zheludochka serdtsa novorozhdennykh krys.

Translated title of the contribution: Lack of low-threshold calcium channels in the membrane of cultured cells of the heart ventricle of newborn rats

A. N. Verkhratskiǐ, N. F. Pronchuk, A. N. Savchenko

    Research output: Contribution to journalArticlepeer-review

    Abstract

    In isolated, cultured neonatal rat ventricular myocytes calcium current was investigated by whole-cell patch clamp technique. The shift of holding potential values from -100-80 mV to -40 mV caused no significant changes in calcium current potential-dependent and kinetic properties. No calcium current component with preferential steady-state inactivation at membrane potentials ranged between -100 and -60 mV was observed. Calcium current component resistant to classic Ca-antagonists action was not found either. All data listed above permit a conclusion on lack of the low-threshold calcium channels in the membrane of single cultured neonatal rat ventricular myocytes. Possible reasons of the absence of this type of calcium are discussed.
    Translated title of the contributionLack of low-threshold calcium channels in the membrane of cultured cells of the heart ventricle of newborn rats
    Original languageRussian
    Pages (from-to)25-31
    Number of pages6
    JournalFiziolohichnyi zhurnal
    Volume37
    Issue number1
    Publication statusPublished - Jan 1991

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