Outcomes and characteristics of nonmelanoma skin cancers in patients with myeloproliferative neoplasms on ruxolitinib

Alex Rampotas, Luke Carter-Brzezinski, Tim C P Somervaille, James Forryan, Fotios Panitsas, Claire Harrison, Ruth Witherall, Andrew J Innes, Louise Wallis, Naumann M Butt, Bethan Psaila, Adam J Mead, Matthew Carter, Anna L Godfrey, Heather Laing, Mamta Garg, Sebastian Francis, Joanne Ewing, Chun Huat Teh, Hannah Bibi CowenPeter Dyer, Conall McConville, Frances Wadelin, Ali Sahra, Andrew McGregor, Elizabeth Kulakov, Donal P McLornan, Jonathan Lambert

Research output: Contribution to journalLetterpeer-review

Abstract

Nonmelanoma skin cancers (NMSCs) in ruxolitinib-treated patients with myeloproliferative neoplasms behave aggressively, with adverse features and high recurrence. In our cohort, mortality from metastatic NMSC exceeded that from myelofibrosis. Vigilant skin assessment, counseling on NMSC risks, and prospective ruxolitinib-NMSC studies are crucial.

Original languageEnglish
Pages (from-to)178-182
Number of pages5
JournalBlood
Volume143
Issue number2
Early online date14 Nov 2023
DOIs
Publication statusPublished - 11 Jan 2024

Keywords

  • Humans
  • Prospective Studies
  • Myeloproliferative Disorders/drug therapy
  • Nitriles
  • Skin Neoplasms/drug therapy
  • Pyrazoles
  • Pyrimidines

Fingerprint

Dive into the research topics of 'Outcomes and characteristics of nonmelanoma skin cancers in patients with myeloproliferative neoplasms on ruxolitinib'. Together they form a unique fingerprint.

Cite this